Detailed information of TA system TA065566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2231717..2232677
• Replicon: chromosome
• Accession: NZ_CP016940
• Organism: Yersinia enterocolitica strain YE5

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM81
• Locus tag: BED32_RS11110
• Protein ID: WP_013649871.1
• Coordinates: 2231717..2232175 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM48
• Locus tag: BED32_RS11115
• Protein ID: WP_013649872.1
• Coordinates: 2232231..2232677 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BED32_RS11080	2227532..2228197	+	666	WP_005161029.1	phage shock protein PspA	-
BED32_RS11085	2228359..2228586	+	228	WP_005161022.1	envelope stress response membrane protein PspB	-
BED32_RS11090	2228586..2228990	+	405	WP_013649869.1	envelope stress response membrane protein PspC	-
BED32_RS11095	2229036..2229275	+	240	WP_005161016.1	phage shock protein PspD	-
BED32_RS11100	2229256..2230653	+	1398	WP_050158954.1	YcjX family protein	-
BED32_RS11105	2230650..2231714	+	1065	WP_049526682.1	YcjF family protein	-
BED32_RS11110	2231717..2232175	-	459	WP_013649871.1	RES family NAD+ phosphorylase	Toxin
BED32_RS11115	2232231..2232677	-	447	WP_013649872.1	DUF2384 domain-containing protein	Antitoxin
BED32_RS11120	2232997..2234574	+	1578	WP_020283144.1	transcriptional regulator TyrR	-
BED32_RS11125	2234821..2235324	-	504	WP_005161000.1	thiol peroxidase	-
BED32_RS11130	2235477..2236448	+	972	WP_049526684.1	L-Ala-D/L-Glu epimerase	-
BED32_RS11135	2236445..2237152	-	708	WP_005160995.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17158.54 Da
• Isoelectric Point: 4.6717

>T65566 WP_013649871.1 NZ_CP016940:c2232175-2231717 [Yersinia enterocolitica]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T65566 NZ_CP016940:c2232175-2231717 [Yersinia enterocolitica]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16322.77 Da
• Isoelectric Point: 9.8753

>AT65566 WP_013649872.1 NZ_CP016940:c2232677-2232231 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT65566 NZ_CP016940:c2232677-2232231 [Yersinia enterocolitica]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7FM81

Antitoxin

• AlphaFold DB: A0A7U7FM48