Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 4777535..4778069 Replicon chromosome
Accession NZ_CP016937
Organism Yersinia enterocolitica strain YE6

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3NX04
Locus tag BED33_RS22150 Protein ID WP_014609469.1
Coordinates 4777770..4778069 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P0C2N3
Locus tag BED33_RS22145 Protein ID WP_005176524.1
Coordinates 4777535..4777777 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED33_RS22120 4773378..4773596 + 219 WP_013749479.1 hypothetical protein -
BED33_RS22125 4773657..4774127 - 471 WP_010891240.1 hypothetical protein -
BED33_RS22135 4774569..4775735 + 1167 WP_010891239.1 plasmid-partitioning protein SopA -
BED33_RS22140 4775732..4776697 + 966 WP_050294053.1 ParB/RepB/Spo0J family plasmid partition protein -
BED33_RS24005 4777077..4777369 + 293 Protein_4332 IS6 family transposase -
BED33_RS22145 4777535..4777777 + 243 WP_005176524.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BED33_RS22150 4777770..4778069 + 300 WP_014609469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BED33_RS22155 4778210..4778869 - 660 WP_072089396.1 type III secretion system effector GTPase activator YopE -
BED33_RS22160 4779062..4779454 + 393 WP_010891236.1 type III secretion system chaperone SycE/YerA -
BED33_RS24010 4779689..4780861 + 1173 Protein_4337 IS3 family transposase -
BED33_RS22175 4781065..4781490 + 426 WP_010891235.1 type III secretion system chaperone SycH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sycT / yopT / yopK/yopQ / yopJ/yopP / yopO/ypkA / yopO/ypkA / yadA / yadA / yopE / sycE/yerA / sycH / yopH 4741389..4783195 41806
- flank IS/Tn - - 4780236..4780739 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11664.24 Da        Isoelectric Point: 5.1053

>T65560 WP_014609469.1 NZ_CP016937:4777770-4778069 [Yersinia enterocolitica]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDAQDFPEYE

Download         Length: 300 bp

>T65560 NZ_CP016937:4777770-4778069 [Yersinia enterocolitica]
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCAGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGCTCAGGATTTTCCAGAGTATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8856.15 Da        Isoelectric Point: 6.7232

>AT65560 WP_005176524.1 NZ_CP016937:4777535-4777777 [Yersinia enterocolitica]
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT65560 NZ_CP016937:4777535-4777777 [Yersinia enterocolitica]
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TACTTGCAGGAACAAATGCACCTGTGAGCCATCGTTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3NX04

Antitoxin

Source ID Structure
AlphaFold DB A1JUB1

References