Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-CC2985
Location 77213..77747 Replicon plasmid unnamed2
Accession NZ_CP016936
Organism Yersinia enterocolitica strain YE7

Toxin (Protein)


Gene name parE Uniprot ID A0A0H3NX04
Locus tag BED34_RS22495 Protein ID WP_014609469.1
Coordinates 77213..77512 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P0C2N3
Locus tag BED34_RS22500 Protein ID WP_005176524.1
Coordinates 77505..77747 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED34_RS22470 73792..74217 - 426 WP_010891235.1 type III secretion system chaperone SycH -
BED34_RS23965 74421..75593 - 1173 Protein_92 IS3 family transposase -
BED34_RS22485 75828..76220 - 393 WP_010891236.1 type III secretion system chaperone SycE/YerA -
BED34_RS22490 76413..77072 + 660 WP_072089396.1 type III secretion system effector GTPase activator YopE -
BED34_RS22495 77213..77512 - 300 WP_014609469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BED34_RS22500 77505..77747 - 243 WP_005176524.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
BED34_RS23970 77913..78205 - 293 Protein_97 IS6 family transposase -
BED34_RS22505 78585..79550 - 966 WP_050294053.1 ParB/RepB/Spo0J family plasmid partition protein -
BED34_RS22510 79547..80713 - 1167 WP_010891239.1 plasmid-partitioning protein SopA -
BED34_RS22515 81155..81625 + 471 WP_010891240.1 hypothetical protein -
BED34_RS22520 81686..81904 - 219 WP_013749479.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - yopH / yopH / sycH / sycE/yerA / yopE / yadA / yopO/ypkA / yopJ/yopP / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / sycH / sycE/yerA / yopE / yadA / yadA 1..88902 88902
- flank IS/Tn - - 74543..75046 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-89)

Antitoxin

(1-79)


Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11664.24 Da        Isoelectric Point: 5.1053

>T65541 WP_014609469.1 NZ_CP016936:c77512-77213 [Yersinia enterocolitica]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDAQDFPEYE

Download         Length: 300 bp

>T65541 NZ_CP016936:c77512-77213 [Yersinia enterocolitica]
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCAGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGCTCAGGATTTTCCAGAGTATGAGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8856.15 Da        Isoelectric Point: 6.7232

>AT65541 WP_005176524.1 NZ_CP016936:c77747-77505 [Yersinia enterocolitica]
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV

Download         Length: 243 bp

>AT65541 NZ_CP016936:c77747-77505 [Yersinia enterocolitica]
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TACTTGCAGGAACAAATGCACCTGTGAGCCATCGTTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3NX04


Antitoxin

Source ID Structure
AlphaFold DB A1JUB1

References