Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-CC2985 |
Location | 77213..77747 | Replicon | plasmid unnamed2 |
Accession | NZ_CP016936 | ||
Organism | Yersinia enterocolitica strain YE7 |
Toxin (Protein)
Gene name | parE | Uniprot ID | A0A0H3NX04 |
Locus tag | BED34_RS22495 | Protein ID | WP_014609469.1 |
Coordinates | 77213..77512 (-) | Length | 100 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P0C2N3 |
Locus tag | BED34_RS22500 | Protein ID | WP_005176524.1 |
Coordinates | 77505..77747 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BED34_RS22470 | 73792..74217 | - | 426 | WP_010891235.1 | type III secretion system chaperone SycH | - |
BED34_RS23965 | 74421..75593 | - | 1173 | Protein_92 | IS3 family transposase | - |
BED34_RS22485 | 75828..76220 | - | 393 | WP_010891236.1 | type III secretion system chaperone SycE/YerA | - |
BED34_RS22490 | 76413..77072 | + | 660 | WP_072089396.1 | type III secretion system effector GTPase activator YopE | - |
BED34_RS22495 | 77213..77512 | - | 300 | WP_014609469.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BED34_RS22500 | 77505..77747 | - | 243 | WP_005176524.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
BED34_RS23970 | 77913..78205 | - | 293 | Protein_97 | IS6 family transposase | - |
BED34_RS22505 | 78585..79550 | - | 966 | WP_050294053.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
BED34_RS22510 | 79547..80713 | - | 1167 | WP_010891239.1 | plasmid-partitioning protein SopA | - |
BED34_RS22515 | 81155..81625 | + | 471 | WP_010891240.1 | hypothetical protein | - |
BED34_RS22520 | 81686..81904 | - | 219 | WP_013749479.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | yopH / yopH / sycH / sycE/yerA / yopE / yadA / yopO/ypkA / yopJ/yopP / yopK/yopQ / yopT / sycT / yopM / yopD / yopB / sycD/lcrH / lcrV / lcrG / lcrR / yscV/lcrD / yscY / yscX / sycN / tyeA / lcrE/yopN / yscN / yscO / yscQ / yscR / yscS / yscT / yscU / virG/yscW / yscB / yscC / yscD / yscE / yscF / yscG / yopR/yscH/lcrP / lcrO/yscI / ylpB/yscJ / yscK / yscL / lcrQ/yscM / yopH / sycH / sycE/yerA / yopE / yadA / yadA | 1..88902 | 88902 | |
- | flank | IS/Tn | - | - | 74543..75046 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11664.24 Da Isoelectric Point: 5.1053
>T65541 WP_014609469.1 NZ_CP016936:c77512-77213 [Yersinia enterocolitica]
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDAQDFPEYE
VYKLSELADEDIYNIASYTIRHFGVTQAKLYHENLAKVFELLAKNLELGAECNWICSDMRRFQYKKHGIYYITLSNDILI
SRVLHQSIDIDAQDFPEYE
Download Length: 300 bp
>T65541 NZ_CP016936:c77512-77213 [Yersinia enterocolitica]
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCAGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGCTCAGGATTTTCCAGAGTATGAGTAG
GTGTATAAACTATCTGAACTGGCTGATGAGGATATTTATAATATTGCCAGTTATACTATCCGGCATTTCGGTGTGACTCA
GGCTAAGTTATACCATGAGAACTTGGCAAAGGTATTCGAGCTATTAGCTAAAAATCTAGAGTTAGGGGCTGAGTGTAACT
GGATTTGCTCAGACATGCGCCGTTTTCAGTATAAAAAGCACGGTATATACTATATAACGCTTAGCAATGATATTTTGATT
TCTCGAGTGCTGCATCAATCCATAGATATAGATGCTCAGGATTTTCCAGAGTATGAGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8856.15 Da Isoelectric Point: 6.7232
>AT65541 WP_005176524.1 NZ_CP016936:c77747-77505 [Yersinia enterocolitica]
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV
MARVTSVTLGEHLTGFVGEMIQSGRYGNISEVLRDALRLMEAREQRVQHVRDMVLAGTNAPVSHRLMDEIFSAAVKDTSV
Download Length: 243 bp
>AT65541 NZ_CP016936:c77747-77505 [Yersinia enterocolitica]
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TACTTGCAGGAACAAATGCACCTGTGAGCCATCGTTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA
ATGGCTCGCGTAACCAGCGTAACACTTGGAGAGCATTTGACAGGTTTTGTGGGGGAAATGATTCAGTCTGGTCGTTATGG
CAATATATCAGAAGTGCTTCGTGATGCCTTAAGGCTAATGGAAGCACGTGAACAGCGTGTTCAACATGTACGCGATATGG
TACTTGCAGGAACAAATGCACCTGTGAGCCATCGTTTAATGGATGAAATTTTTTCTGCTGCGGTGAAAGATACTAGTGTA
TAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3NX04 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A1JUB1 |