Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3708264..3708936 Replicon chromosome
Accession NZ_CP016935
Organism Yersinia enterocolitica strain YE7

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag BED34_RS17835 Protein ID WP_005166047.1
Coordinates 3708264..3708689 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag BED34_RS17840 Protein ID WP_004390965.1
Coordinates 3708670..3708936 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED34_RS17815 3704038..3704556 + 519 WP_005166042.1 flavodoxin FldB -
BED34_RS17820 3704615..3706036 - 1422 WP_049527976.1 cell envelope integrity protein CreD -
BED34_RS17825 3706128..3707555 - 1428 WP_049527980.1 two-component system sensor histidine kinase CreC -
BED34_RS17830 3707566..3708264 - 699 WP_005166045.1 two-component system response regulator CreB -
BED34_RS17835 3708264..3708689 - 426 WP_005166047.1 protein YgfX Toxin
BED34_RS17840 3708670..3708936 - 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
BED34_RS17845 3709203..3710195 + 993 WP_049527983.1 tRNA-modifying protein YgfZ -
BED34_RS17850 3710391..3711410 + 1020 WP_084738255.1 IS110 family transposase -
BED34_RS17855 3711821..3712504 - 684 WP_050155820.1 hemolysin III family protein -
BED34_RS17860 3712735..3713337 + 603 WP_069009466.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3710391..3711410 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T65536 WP_005166047.1 NZ_CP016935:c3708689-3708264 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

>T65536 NZ_CP016935:c3708689-3708264 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCACTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT65536 WP_004390965.1 NZ_CP016935:c3708936-3708670 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT65536 NZ_CP016935:c3708936-3708670 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References