Detailed information of TA system TA065526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2299071..2300031
• Replicon: chromosome
• Accession: NZ_CP016935
• Organism: Yersinia enterocolitica strain YE7

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM81
• Locus tag: BED34_RS11495
• Protein ID: WP_013649871.1
• Coordinates: 2299071..2299529 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM48
• Locus tag: BED34_RS11500
• Protein ID: WP_013649872.1
• Coordinates: 2299585..2300031 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BED34_RS11465	2294886..2295551	+	666	WP_005161029.1	phage shock protein PspA	-
BED34_RS11470	2295713..2295940	+	228	WP_005161022.1	envelope stress response membrane protein PspB	-
BED34_RS11475	2295940..2296344	+	405	WP_013649869.1	envelope stress response membrane protein PspC	-
BED34_RS11480	2296390..2296629	+	240	WP_005161016.1	phage shock protein PspD	-
BED34_RS11485	2296610..2298007	+	1398	WP_050158954.1	YcjX family protein	-
BED34_RS11490	2298004..2299068	+	1065	WP_049526682.1	YcjF family protein	-
BED34_RS11495	2299071..2299529	-	459	WP_013649871.1	RES family NAD+ phosphorylase	Toxin
BED34_RS11500	2299585..2300031	-	447	WP_013649872.1	DUF2384 domain-containing protein	Antitoxin
BED34_RS11505	2300351..2301928	+	1578	WP_020283144.1	transcriptional regulator TyrR	-
BED34_RS11510	2302175..2302678	-	504	WP_005161000.1	thiol peroxidase	-
BED34_RS11515	2302831..2303802	+	972	WP_049526684.1	L-Ala-D/L-Glu epimerase	-
BED34_RS11520	2303799..2304506	-	708	WP_005160995.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17158.54 Da
• Isoelectric Point: 4.6717

>T65526 WP_013649871.1 NZ_CP016935:c2299529-2299071 [Yersinia enterocolitica]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T65526 NZ_CP016935:c2299529-2299071 [Yersinia enterocolitica]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16322.77 Da
• Isoelectric Point: 9.8753

>AT65526 WP_013649872.1 NZ_CP016935:c2300031-2299585 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT65526 NZ_CP016935:c2300031-2299585 [Yersinia enterocolitica]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7FM81

Antitoxin

• AlphaFold DB: A0A7U7FM48