Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4205425..4205960 Replicon chromosome
Accession NZ_CP016931
Organism Yersinia enterocolitica strain YE165

Toxin (Protein)


Gene name relE Uniprot ID A0A7U7G363
Locus tag BB936_RS19435 Protein ID WP_049528305.1
Coordinates 4205425..4205712 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U7FI63
Locus tag BB936_RS19440 Protein ID WP_005156229.1
Coordinates 4205709..4205960 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BB936_RS19405 4200685..4201491 + 807 WP_069018168.1 phosphonate C-P lyase system protein PhnK -
BB936_RS19410 4201505..4202239 + 735 WP_005156211.1 phosphonate C-P lyase system protein PhnL -
BB936_RS19415 4202236..4203384 + 1149 WP_005156213.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
BB936_RS19420 4203384..4203923 + 540 Protein_3804 ribose 1,5-bisphosphokinase -
BB936_RS19425 4203952..4204719 + 768 WP_050126339.1 phosphonate metabolism protein PhnP -
BB936_RS19430 4204720..4205349 - 630 WP_050126398.1 hypothetical protein -
BB936_RS19435 4205425..4205712 - 288 WP_049528305.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BB936_RS19440 4205709..4205960 - 252 WP_005156229.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BB936_RS19445 4206168..4206620 - 453 WP_005181269.1 YhbP family protein -
BB936_RS19450 4206694..4207860 - 1167 WP_013649156.1 alginate lyase family protein -
BB936_RS19455 4207874..4208989 - 1116 WP_005156237.1 ABC transporter ATP-binding protein -
BB936_RS19460 4209001..4209840 - 840 WP_005156238.1 carbohydrate ABC transporter permease -
BB936_RS19465 4209859..4210743 - 885 WP_005156239.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11016.10 Da        Isoelectric Point: 10.3544

>T65519 WP_049528305.1 NZ_CP016931:c4205712-4205425 [Yersinia enterocolitica]
MIYKLKFRSDALKEWGKIDKVIQQQFAKKLKKCCENPHIPSAKLRGLSDCYKIKLRASGFRLVYQVIEDCLVIAVVAVGK
RERSDVYNLASERLR

Download         Length: 288 bp

>T65519 NZ_CP016931:c4205712-4205425 [Yersinia enterocolitica]
ATGATTTATAAATTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9270.65 Da        Isoelectric Point: 4.2264

>AT65519 WP_005156229.1 NZ_CP016931:c4205960-4205709 [Yersinia enterocolitica]
MANIILSDTSASVSELKKNPMATVKAGAGYPVAILNRNQPAFYCIPAELYERMLDALDDQELIRLVTERESQPLIDVDLD
KYL

Download         Length: 252 bp

>AT65519 NZ_CP016931:c4205960-4205709 [Yersinia enterocolitica]
ATGGCTAACATAATTTTAAGTGATACGAGCGCAAGTGTCAGCGAGTTAAAGAAAAACCCTATGGCCACAGTCAAAGCGGG
GGCGGGCTATCCAGTGGCTATTTTGAATAGAAACCAACCGGCATTTTATTGTATCCCCGCAGAATTATACGAGAGAATGC
TAGATGCCCTTGATGATCAAGAGCTTATCAGATTAGTTACCGAACGAGAGAGTCAGCCACTCATTGATGTAGATCTGGAT
AAGTATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7G363

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FI63

References