Detailed information of TA system TA065508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2470100..2471060
• Replicon: chromosome
• Accession: NZ_CP016931
• Organism: Yersinia enterocolitica strain YE165

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM81
• Locus tag: BB936_RS11785
• Protein ID: WP_013649871.1
• Coordinates: 2470602..2471060 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A7U7FM48
• Locus tag: BB936_RS11780
• Protein ID: WP_013649872.1
• Coordinates: 2470100..2470546 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BB936_RS11760	2465625..2466332	+	708	WP_005160995.1	murein tripeptide amidase MpaA	-
BB936_RS11765	2466329..2467300	-	972	WP_049526684.1	L-Ala-D/L-Glu epimerase	-
BB936_RS11770	2467453..2467956	+	504	WP_005161000.1	thiol peroxidase	-
BB936_RS11775	2468203..2469780	-	1578	WP_020283144.1	transcriptional regulator TyrR	-
BB936_RS11780	2470100..2470546	+	447	WP_013649872.1	DUF2384 domain-containing protein	Antitoxin
BB936_RS11785	2470602..2471060	+	459	WP_013649871.1	RES family NAD+ phosphorylase	Toxin
BB936_RS11790	2471063..2472127	-	1065	WP_049526682.1	YcjF family protein	-
BB936_RS11795	2472124..2473521	-	1398	WP_050156133.1	YcjX family protein	-
BB936_RS11800	2473502..2473741	-	240	WP_069018086.1	phage shock protein PspD	-
BB936_RS11805	2473787..2474191	-	405	WP_013649869.1	envelope stress response membrane protein PspC	-
BB936_RS11810	2474191..2474418	-	228	WP_005161022.1	envelope stress response membrane protein PspB	-
BB936_RS11815	2474580..2475245	-	666	WP_005161029.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17158.54 Da
• Isoelectric Point: 4.6717

>T65508 WP_013649871.1 NZ_CP016931:2470602-2471060 [Yersinia enterocolitica]
MILYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAAIYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIEDSNIMLLQPQ
DWPTNWRSDPAPATTMDIGTEWLESESSLGLLVPSTLVPTENNLLLNPQHKSFQACLSSVQPLSFAFDPRLK

Nucleotide

• Length: 459 bp

>T65508 NZ_CP016931:2470602-2471060 [Yersinia enterocolitica]
ATGATACTCTACCGCATCGTGATGCGCCGCTATCTTGCCTCAACCTGGACCGGCTATGGTGCCGAAATCTATGGTGGCCG
CTGGAACCATAAGGGGCACGCCGCCATCTACTTAGCCAGCAGTGTATCACTGGCGATGTTGGAGACATTGGTACATATTC
AGGACAGCTCAACACTGAGTGAGTTCGAGTTATTCCAAATTGAAATCGAAGATAGCAACATTATGCTGCTTCAGCCGCAA
GATTGGCCCACGAACTGGCGTAGCGACCCCGCACCTGCGACCACAATGGATATCGGCACTGAATGGCTGGAATCAGAATC
ATCACTCGGATTACTGGTTCCATCCACTCTGGTGCCGACAGAAAACAATCTGCTGCTCAACCCTCAACACAAAAGTTTTC
AAGCCTGTTTAAGCAGTGTTCAACCACTCTCTTTTGCCTTTGACCCACGGCTGAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16322.77 Da
• Isoelectric Point: 9.8753

>AT65508 WP_013649872.1 NZ_CP016931:2470100-2470546 [Yersinia enterocolitica]
MRAYHPTPATKTRALWREIGLPASRGTVLVDSIKMGFSVDVIDSIHLWASIPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLVGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT65508 NZ_CP016931:2470100-2470546 [Yersinia enterocolitica]
ATGAGAGCATATCACCCCACTCCAGCGACTAAAACAAGGGCGCTATGGCGAGAGATTGGTTTGCCCGCCAGCCGCGGTAC
TGTATTGGTCGATAGCATCAAAATGGGTTTTTCTGTTGATGTCATTGACAGCATTCATCTATGGGCATCTATTCCAAAAG
CTGAAATCTTGCGTGCGACCGGTATTCCCAGCCGTAGCTTGACCCGCAGACGCACCCATGATGGCCGTTTCACTCCCGAA
GAGAGTGAGCGCATTGCGCGCTTCGTGCGGGTTATGGACGCCGCAGTTGATCTATTTGGCGGAGATAAAGGCAAAGCTAT
CACTTGGATGTCGACCCCGATTAAAGGCCTGGGCCACCGTAGTCCGGATTCCTTACTGGAAACTGAAACCGGTGCATTGG
AAGTCTGTGATTTGGTTGGACGCCTGGAGCACGGCGTATTTTCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7FM81

Antitoxin

• AlphaFold DB: A0A7U7FM48