Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4043545..4044170 Replicon chromosome
Accession NZ_CP016928
Organism Dickeya solani RNS 08.23.3.1.A

Toxin (Protein)


Gene name Hha Uniprot ID A0A2K8W3K4
Locus tag D083_RS17825 Protein ID WP_022632574.1
Coordinates 4043545..4043748 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2K8W3I1
Locus tag D083_RS17830 Protein ID WP_022632575.1
Coordinates 4043802..4044170 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D083_RS17795 4039185..4039523 + 339 WP_002208627.1 P-II family nitrogen regulator -
D083_RS17800 4039566..4040858 + 1293 WP_022632570.1 ammonium transporter AmtB -
D083_RS17805 4040954..4041817 - 864 WP_022632571.1 acyl-CoA thioesterase II -
D083_RS17810 4042069..4042626 + 558 WP_022632572.1 YbaY family lipoprotein -
D083_RS17815 4042655..4042984 - 330 WP_022632573.1 MGMT family protein -
D083_RS17825 4043545..4043748 - 204 WP_022632574.1 hemolysin expression modulator Hha Toxin
D083_RS17830 4043802..4044170 - 369 WP_022632575.1 Hha toxicity modulator TomB Antitoxin
D083_RS17835 4044678..4044821 - 144 WP_022632576.1 type B 50S ribosomal protein L36 -
D083_RS17840 4044837..4045088 - 252 WP_022632577.1 type B 50S ribosomal protein L31 -
D083_RS17845 4045265..4048411 - 3147 WP_022632578.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.52 Da        Isoelectric Point: 8.8580

>T65499 WP_022632574.1 NZ_CP016928:c4043748-4043545 [Dickeya solani RNS 08.23.3.1.A]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T65499 NZ_CP016928:c4043748-4043545 [Dickeya solani RNS 08.23.3.1.A]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGCACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCCAACGATGAGCTTGAAATGTTCTATTCAGCTGCAGATCACCGCCTGGCAGAGCTGACGATGAATAAGC
TTTACGACAAAGTACCGACTGCTGTGTGGAGATACGTTCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14223.06 Da        Isoelectric Point: 5.1663

>AT65499 WP_022632575.1 NZ_CP016928:c4044170-4043802 [Dickeya solani RNS 08.23.3.1.A]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSKSQLFRMFSEKSICTVVKT

Download         Length: 369 bp

>AT65499 NZ_CP016928:c4044170-4043802 [Dickeya solani RNS 08.23.3.1.A]
ATGGATGAGTACACACCCCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
GACATTAGGTGACAGCAGTCATGGCTGGGTGAATGATCCGACCTCTGCGGTCAACCTTCAACTAAACGAACTTATCGAGC
ATATTGCGGCATTTGTTGTTACCTACAAAATAAAATACCCGCATGAAGCGGCGCTATGTGAACGGGTTGAGAAATATCTG
GACGACACTTATATTCTTTTCAGCAATTACGGTATCAATGACACCGAGTTGCGGAAATGGCAAAAATCCAAGTCACAATT
ATTCAGAATGTTCTCAGAAAAGAGCATCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W3K4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W3I1

References