Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3419264..3419790 Replicon chromosome
Accession NZ_CP016928
Organism Dickeya solani RNS 08.23.3.1.A

Toxin (Protein)


Gene name ccdB Uniprot ID A0A2K8W1W4
Locus tag D083_RS14995 Protein ID WP_022632051.1
Coordinates 3419264..3419569 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2K8W1V7
Locus tag D083_RS15000 Protein ID WP_022632052.1
Coordinates 3419572..3419790 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D083_RS14975 3414492..3414889 + 398 Protein_2884 DUF3577 domain-containing protein -
D083_RS14980 3415005..3416276 + 1272 WP_022632048.1 hypothetical protein -
D083_RS14985 3416280..3416846 + 567 WP_024103901.1 hypothetical protein -
D083_RS14990 3416834..3418774 + 1941 WP_022632050.1 hypothetical protein -
D083_RS14995 3419264..3419569 - 306 WP_022632051.1 type II toxin-antitoxin system toxin CcdB Toxin
D083_RS15000 3419572..3419790 - 219 WP_022632052.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
D083_RS15005 3419849..3420592 - 744 WP_022632053.1 hypothetical protein -
D083_RS15015 3421495..3421845 - 351 WP_013316250.1 hypothetical protein -
D083_RS21640 3421968..3422156 + 189 WP_033111580.1 hypothetical protein -
D083_RS15020 3422296..3423555 - 1260 WP_022632055.1 integrase arm-type DNA-binding domain-containing protein -
D083_RS15030 3423953..3424528 - 576 WP_022632056.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3413413..3423732 10319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11779.68 Da        Isoelectric Point: 4.8837

>T65497 WP_022632051.1 NZ_CP016928:c3419569-3419264 [Dickeya solani RNS 08.23.3.1.A]
MQFIVYEYKRASHYKMFVDVQSDIVETPKRRMVIPLIEAHHLSEKVNKTLFPKIRIDGEDYRLMTTELSSVPVEVMGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T65497 NZ_CP016928:c3419569-3419264 [Dickeya solani RNS 08.23.3.1.A]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAGAGTGATATCGTCGAGAC
ACCCAAGCGGCGCATGGTCATTCCGCTTATCGAAGCACACCACCTGTCTGAGAAAGTGAATAAGACGTTGTTCCCTAAGA
TCCGCATCGACGGCGAAGATTATCGGCTGATGACGACTGAACTATCGAGCGTACCTGTTGAAGTCATGGGTGAAGTGATT
GCGGATCTTGGCGACTACGCGGATGAGATTAAGGATGCTATTAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8109.02 Da        Isoelectric Point: 5.8316

>AT65497 WP_022632052.1 NZ_CP016928:c3419790-3419572 [Dickeya solani RNS 08.23.3.1.A]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEEWKKENSEGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT65497 NZ_CP016928:c3419790-3419572 [Dickeya solani RNS 08.23.3.1.A]
ATGAAACACCGCGTCAGTGTTACCGTAGACAAAGACAACTATCAGGTTCTGAGTGCTGCCGGAGTCAACATTTCTGGGCT
GGTGAACGATGCCATTGGCAAAGAAGCCCGCCGTATCAAGGCTGAGGAGTGGAAGAAAGAAAACAGTGAGGGGATGGAGG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W1W4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W1V7

References