Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2814909..2816497 Replicon chromosome
Accession NZ_CP016928
Organism Dickeya solani RNS 08.23.3.1.A

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8W078
Locus tag D083_RS12125 Protein ID WP_022635525.1
Coordinates 2815178..2816497 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2K8W0B1
Locus tag D083_RS12120 Protein ID WP_022635524.1
Coordinates 2814909..2815178 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D083_RS12095 2810227..2810838 - 612 WP_022635519.1 NAD(P)-dependent oxidoreductase -
D083_RS12100 2810980..2811366 + 387 WP_022635520.1 helix-turn-helix transcriptional regulator -
D083_RS12105 2811465..2812550 - 1086 WP_022635521.1 4-hydroxyphenylpyruvate dioxygenase -
D083_RS12110 2812865..2813638 + 774 WP_022635522.1 MBL fold metallo-hydrolase -
D083_RS12115 2813682..2814638 + 957 WP_026595316.1 helix-turn-helix domain-containing protein -
D083_RS12120 2814909..2815178 + 270 WP_022635524.1 helix-turn-helix domain-containing protein Antitoxin
D083_RS12125 2815178..2816497 + 1320 WP_022635525.1 type II toxin-antitoxin system HipA family toxin Toxin
D083_RS12130 2816569..2817933 - 1365 WP_022635526.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
D083_RS12135 2818049..2819680 - 1632 WP_022635527.1 membrane protein insertase YidC -
D083_RS12140 2819683..2819940 - 258 WP_071598660.1 membrane protein insertion efficiency factor YidD -
D083_RS12145 2819904..2820263 - 360 WP_022635528.1 ribonuclease P protein component -
D083_RS12150 2820282..2820422 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49161.32 Da        Isoelectric Point: 6.6616

>T65495 WP_022635525.1 NZ_CP016928:2815178-2816497 [Dickeya solani RNS 08.23.3.1.A]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLELPGSRPLSLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVTRHQ
ADSTQPFDLLAKVGQDSVGALQLVPQGTAVGDIKQIEYKTLSEQQLENILAGYLSDAPLGMIDTEEDFRISIAGAQEKTA
LLYLDGSWCLPLNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLSVPHCFMITAGKIKALAVERFDRK
YASDGRWIMRLPQEDFCQVLNVPSARKYENHGGPGISAIMSVLLGAIEPERDRYTFMKAQVLFWLLAATDGHAKNFSLFI
EFEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAKVVGFARESMERILTEFSQTV
DSVIVSVRNQLPADFPTPIRDAILGGLQTRSSRLTTGWE

Download         Length: 1320 bp

>T65495 NZ_CP016928:2815178-2816497 [Dickeya solani RNS 08.23.3.1.A]
ATGGCGGCGCTCGATGTTTACATGAACGGCTACCGGGTGGGAATTCTGACCAAAACGGGCAGTGGCGCGCATCATTTTTC
CTATGATGCGAACTGGCTCGAGTTGCCGGGGAGTCGCCCCCTCTCGCTCTCAATGCCGCTACGCCATCAGCCCTATCAAG
GTGATGAAGTTTATAATTTCTTCGACAACTTGTTGCCGGATAACCCGGATATCAGGCGGCGGATTGTCACCAGGCATCAG
GCGGATTCCACCCAGCCGTTTGATTTGCTGGCTAAAGTGGGGCAAGACAGTGTTGGGGCGTTGCAATTGGTGCCGCAGGG
CACCGCTGTTGGCGATATAAAACAGATCGAATACAAAACCTTATCCGAGCAACAGCTTGAAAACATACTGGCGGGATATC
TGTCCGATGCCCCGCTCGGGATGATTGATACAGAAGAGGATTTTCGTATCTCTATCGCAGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGGCAGCTGGTGTTTGCCTCTTAATACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATTGAGAGTCATTCATACTCAATTGATATGTCTGACAGCGTTGAAAATGAATACCTGTGCCTGCTCATTGCCAAGGCGT
TTGGGCTGTCGGTACCGCACTGTTTTATGATCACAGCAGGCAAGATAAAAGCGCTGGCGGTAGAACGTTTTGATCGTAAA
TACGCCTCGGATGGTCGTTGGATTATGCGGTTGCCGCAGGAGGATTTTTGCCAGGTATTAAACGTGCCTTCCGCACGAAA
ATACGAAAATCATGGTGGACCGGGCATTTCCGCTATTATGTCGGTGCTATTAGGGGCGATTGAACCTGAAAGGGATCGCT
ATACCTTTATGAAGGCGCAGGTGCTGTTTTGGCTATTGGCTGCAACGGATGGACATGCAAAAAACTTCTCCCTGTTTATT
GAATTTGAAGGACGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGCGGGCGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGGCTGACCGGCTCAAAAGGCAAGAAATACGCCATTGAGCAGATCTTTCCACGGC
ACTTTTTCCAAACGGCAAAGGTGGTTGGATTTGCCAGAGAATCGATGGAACGCATTCTGACTGAATTTTCACAGACGGTT
GATTCTGTCATCGTGAGTGTCAGAAACCAACTGCCTGCGGATTTTCCCACTCCTATCCGCGATGCGATCCTGGGAGGGCT
ACAGACTAGATCGAGTCGATTGACGACGGGCTGGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9950.26 Da        Isoelectric Point: 10.0983

>AT65495 WP_022635524.1 NZ_CP016928:2814909-2815178 [Dickeya solani RNS 08.23.3.1.A]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTITPRNAHAANNEASV
ATSAWKEEW

Download         Length: 270 bp

>AT65495 NZ_CP016928:2814909-2815178 [Dickeya solani RNS 08.23.3.1.A]
ATGAAGGTCACCAACAGCAAACAGCTTAGCAGCTATCTAAAAGATGTTCGTATCACGCAGAAGCTTTCCCAAGGGAAAGT
GGCCAGTAAAGTGGGGATTCGTCAGGACACGGTATCGAGCTTCGAACAACATCCCGATTCCACCAAGCTGGAAACCTTCT
TTAAGATCCTGTCGGCATTAAATTTAGAACTTACCATTACCCCCAGAAATGCGCATGCAGCCAATAACGAGGCTTCTGTT
GCAACATCAGCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8W078

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8W0B1

References