Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1665950..1667790 Replicon chromosome
Accession NZ_CP016928
Organism Dickeya solani RNS 08.23.3.1.A

Toxin (Protein)


Gene name hipA Uniprot ID A0A2K8VX87
Locus tag D083_RS07220 Protein ID WP_022634631.1
Coordinates 1666444..1667790 (-) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D083_RS07215 Protein ID WP_099048985.1
Coordinates 1665950..1666333 (-) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D083_RS07190 1661267..1662106 - 840 WP_022634625.1 MurR/RpiR family transcriptional regulator -
D083_RS07195 1662281..1663870 + 1590 WP_022634626.1 gamma-glutamyltransferase family protein -
D083_RS07200 1663915..1664112 + 198 WP_022634627.1 oxalurate catabolism protein HpxX -
D083_RS07205 1664109..1665521 + 1413 WP_022634628.1 AtzE family amidohydrolase -
D083_RS07210 1665518..1665898 + 381 WP_022634629.1 oxalurate catabolism protein HpxZ -
D083_RS07215 1665950..1666333 - 384 WP_099048985.1 helix-turn-helix domain-containing protein Antitoxin
D083_RS07220 1666444..1667790 - 1347 WP_022634631.1 type II toxin-antitoxin system HipA family toxin Toxin
D083_RS07225 1668063..1669010 - 948 WP_022634632.1 allantoinase PuuE -
D083_RS07230 1669054..1669791 - 738 WP_022634633.1 allantoin racemase -
D083_RS07235 1669788..1670531 - 744 WP_022634634.1 GntR family transcriptional regulator -
D083_RS07240 1670684..1672168 + 1485 WP_022634635.1 NCS1 family nucleobase:cation symporter-1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-392)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-104)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50541.28 Da        Isoelectric Point: 4.9663

>T65494 WP_022634631.1 NZ_CP016928:c1667790-1666444 [Dickeya solani RNS 08.23.3.1.A]
MERLTVQAFIDNAWQDIAEIGFPESDQDNYLLTRLDYASDYGLDYMDCDDHHAVSVNYPVRIFFDDGGELGWMRFLDDIM
PAGASRKYWVDHLDLSGLPAPLQNYVLLRHATIAPVGNLRIKESIPVRHEGATRFFSVEDVKNRAADFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDRVWIDTWQDKTDCRDTAYLVKFPRGQRSEIDCDILRAEFHYYHELAAMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGDGRVKRYGMESVYSLLRAGPGSALRHDQTIRAVIAKIASSHTVSVEGKPFDQAAFVIEWV
RRDVLNIAFGNSDNHGRNTAFLKDEQGIRLAPIYDFAPMKADPAGIARATKWPEPLEIGGDYQFEWIAEQLSDMLPPALL
MERLRETAVQLVGLKARLQARGVPESILTMPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

>T65494 NZ_CP016928:c1667790-1666444 [Dickeya solani RNS 08.23.3.1.A]
ATGGAACGACTGACTGTACAGGCGTTTATCGATAATGCGTGGCAGGATATTGCCGAGATCGGTTTTCCCGAGAGCGACCA
GGATAATTACCTGCTGACCCGGCTGGATTATGCGTCCGATTATGGCCTTGACTATATGGATTGCGACGACCACCACGCGG
TTTCCGTCAATTACCCGGTTCGGATCTTCTTTGATGATGGCGGTGAGCTCGGATGGATGCGCTTTCTGGATGACATCATG
CCGGCGGGGGCCAGCCGAAAATATTGGGTTGACCACCTTGATCTCTCGGGGCTGCCGGCACCGTTGCAAAATTATGTCTT
GCTGCGGCATGCCACCATCGCACCGGTCGGTAATTTGCGCATCAAGGAGTCGATTCCTGTGCGGCATGAAGGTGCAACCC
GCTTTTTCAGCGTGGAGGATGTGAAGAACCGGGCTGCCGATTTTCTGGATTATGCGCAGCAGCGCGGTGCCGCTGCCGGG
GGCGCTACAGGGGCGGGCGGTGAGGCGCCAAAGCTGCTGTTGCGTTGTAATGCCGACGATCGGGTGTGGATCGATACCTG
GCAGGATAAGACCGACTGCCGCGATACCGCCTATCTGGTGAAGTTTCCGCGCGGGCAACGCAGTGAGATTGACTGCGACA
TCCTGCGGGCCGAGTTTCATTACTACCATGAATTAGCCGCGATGGGGTTCGACACCATTCCTGTGGCGGGCATGCGTCTG
GAAGAGGGGCGGCATTACCCGTCGCTCTGGTTGCCGCGTTTTGATATCGAATTCCCCGGCGATGGGCGCGTGAAGCGTTA
TGGCATGGAATCAGTTTATTCCCTGTTGCGGGCCGGGCCGGGCAGCGCGCTGCGGCACGATCAAACGATTCGGGCGGTGA
TCGCCAAAATAGCGTCCAGCCATACGGTCAGCGTCGAGGGAAAGCCATTCGACCAAGCGGCGTTCGTGATCGAGTGGGTG
CGCCGCGATGTGCTGAATATTGCCTTCGGCAACAGCGATAACCACGGCCGCAATACCGCGTTTCTCAAGGACGAACAGGG
GATTCGGCTGGCGCCGATTTACGACTTCGCGCCGATGAAGGCCGACCCGGCAGGCATTGCCAGAGCGACCAAATGGCCGG
AGCCGCTGGAAATCGGCGGTGATTATCAGTTTGAGTGGATCGCGGAGCAGTTGTCCGACATGCTCCCGCCGGCGCTGTTG
ATGGAGAGATTGCGCGAGACGGCGGTGCAACTGGTTGGACTGAAAGCGCGGCTTCAGGCGCGCGGTGTGCCCGAGTCGAT
CCTAACCATGCCTTCCATCGGGTTTGATTACCTTCCTGAAAAGCTACAGCGGTGGGGGTTGTTATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13731.06 Da        Isoelectric Point: 10.8242

>AT65494 WP_099048985.1 NZ_CP016928:c1666333-1665950 [Dickeya solani RNS 08.23.3.1.A]
MLRPPVIAVAETADIPKARASKNSRPLNASERQSAMQSIIRRMMVGEISQGNALRELRLSVLGLKQDAYASLVGVSRKTL
SEIENDKGNYTADIINKVFKPFGLKMGLIPVSPSLLAEILATAPASR

Download         Length: 384 bp

>AT65494 NZ_CP016928:c1666333-1665950 [Dickeya solani RNS 08.23.3.1.A]
ATGCTGCGTCCCCCGGTCATTGCCGTGGCGGAGACGGCGGATATTCCCAAAGCGAGAGCATCAAAAAATTCCAGACCACT
CAATGCCAGTGAGAGACAGTCTGCGATGCAAAGCATTATCCGCAGGATGATGGTCGGGGAGATATCGCAGGGAAACGCGC
TCAGGGAATTGCGTCTCAGCGTTCTGGGGCTCAAGCAGGATGCCTACGCCAGTCTGGTAGGCGTGTCGCGCAAGACCTTG
TCCGAAATCGAGAATGACAAAGGCAATTACACGGCGGATATCATCAACAAGGTCTTTAAACCCTTTGGTCTGAAGATGGG
ATTAATTCCGGTATCGCCTTCTTTGCTCGCCGAGATACTCGCCACCGCGCCAGCCTCTCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8VX87

Antitoxin

Source ID Structure

References