Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 618056..618651 Replicon chromosome
Accession NZ_CP016928
Organism Dickeya solani RNS 08.23.3.1.A

Toxin (Protein)


Gene name doc Uniprot ID E0SEA8
Locus tag D083_RS02655 Protein ID WP_013318177.1
Coordinates 618056..618433 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2K8VUJ6
Locus tag D083_RS02660 Protein ID WP_022633800.1
Coordinates 618430..618651 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D083_RS02635 613722..613988 + 267 WP_022633797.1 hypothetical protein -
D083_RS02640 614220..614402 + 183 WP_072142890.1 hypothetical protein -
D083_RS02645 614484..616250 - 1767 WP_022633798.1 ATP-binding protein -
D083_RS02650 616240..617418 - 1179 WP_022633799.1 hypothetical protein -
D083_RS02655 618056..618433 - 378 WP_013318177.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
D083_RS02660 618430..618651 - 222 WP_022633800.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
D083_RS02665 618792..619940 - 1149 WP_022633801.1 L-threonine dehydrogenase -
D083_RS02670 620222..620782 + 561 WP_026594485.1 NUDIX domain-containing protein -
D083_RS02675 620854..621531 - 678 WP_022633803.1 respiratory nitrate reductase subunit gamma -
D083_RS02680 621531..622250 - 720 WP_022633804.1 nitrate reductase molybdenum cofactor assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14320.39 Da        Isoelectric Point: 4.9309

>T65493 WP_013318177.1 NZ_CP016928:c618433-618056 [Dickeya solani RNS 08.23.3.1.A]
MKWVSAQDVIDFHDRILQVLPGVVGMADPGRAEELIYRVQNRLYYEGVTELFELAATYWVTIARGHIFNDGNKRTAFFVT
MTFLRRNGILIVDNDNSLEELTIKAATGECLVSELAEQLRQRVEK

Download         Length: 378 bp

>T65493 NZ_CP016928:c618433-618056 [Dickeya solani RNS 08.23.3.1.A]
ATGAAATGGGTGAGTGCGCAGGACGTCATTGACTTCCATGATCGTATTTTGCAGGTGTTGCCTGGTGTGGTGGGTATGGC
TGATCCGGGTCGGGCTGAGGAGTTGATTTATCGAGTACAAAACCGTCTTTATTATGAAGGTGTGACCGAACTGTTTGAGT
TGGCGGCGACGTATTGGGTAACTATTGCTCGTGGTCATATTTTTAATGATGGCAATAAACGCACTGCTTTTTTTGTTACC
ATGACATTTTTGCGCCGCAATGGCATATTGATTGTCGATAACGATAATTCGCTGGAAGAACTCACCATTAAGGCGGCAAC
CGGAGAATGCCTGGTGTCGGAACTCGCCGAACAATTAAGACAACGGGTGGAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8207.33 Da        Isoelectric Point: 7.2021

>AT65493 WP_022633800.1 NZ_CP016928:c618651-618430 [Dickeya solani RNS 08.23.3.1.A]
MKTYTITEARQNIATVIDTAASGEPVEIKRRDGTSAVLIPKAEFEAYQKARLDAEFDFIMQRHGHTIKALADR

Download         Length: 222 bp

>AT65493 NZ_CP016928:c618651-618430 [Dickeya solani RNS 08.23.3.1.A]
ATGAAGACTTATACCATTACTGAAGCCCGGCAAAATATTGCGACAGTCATTGATACGGCGGCCAGCGGTGAGCCGGTAGA
GATTAAGCGTCGGGATGGCACCTCGGCTGTACTCATCCCCAAAGCAGAGTTTGAGGCTTATCAGAAAGCCAGATTAGACG
CTGAATTCGATTTCATCATGCAGCGCCACGGACACACAATCAAAGCGCTCGCCGACAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SEA8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8VUJ6

References