Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 269079..269830 Replicon plasmid pIncHI1B_DHQP1300920
Accession NZ_CP016921
Organism Klebsiella pneumoniae isolate 11

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag A8C11_RS01785 Protein ID WP_014386536.1
Coordinates 269348..269830 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag A8C11_RS01780 Protein ID WP_004902250.1
Coordinates 269079..269357 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8C11_RS30765 264722..265147 - 426 WP_000522996.1 organomercurial transporter MerC -
A8C11_RS30770 265175..265450 - 276 WP_043907009.1 mercury resistance system periplasmic binding protein MerP -
A8C11_RS30410 265466..265831 - 366 WP_004200999.1 mercuric ion transporter MerT -
A8C11_RS01755 265903..266358 + 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
A8C11_RS01760 267011..267469 + 459 WP_014386535.1 hypothetical protein -
A8C11_RS01770 268299..268640 + 342 WP_004902257.1 hypothetical protein -
A8C11_RS01775 268748..268960 + 213 WP_004902255.1 hypothetical protein -
A8C11_RS01780 269079..269357 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
A8C11_RS01785 269348..269830 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
A8C11_RS01795 270865..271404 + 540 WP_004902239.1 hypothetical protein -
A8C11_RS01800 271509..271901 + 393 WP_032442757.1 hypothetical protein -
A8C11_RS01805 272002..272757 + 756 WP_004902235.1 DUF2971 domain-containing protein -
A8C11_RS01810 272784..273431 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaNDM-1 / aph(3')-VI / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / dfrA14 / blaOXA-1 / aac(6')-Ib-cr / qnrB1 - 1..283369 283369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T65448 WP_014386536.1 NZ_CP016921:269348-269830 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T65448 NZ_CP016921:269348-269830 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT65448 WP_004902250.1 NZ_CP016921:269079-269357 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT65448 NZ_CP016921:269079-269357 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References