Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 894442..895078 Replicon chromosome
Accession NZ_CP016916
Organism Parageobacillus thermoglucosidasius strain TM242

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag BCV54_RS04510 Protein ID WP_003253417.1
Coordinates 894728..895078 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A178U3Z0
Locus tag BCV54_RS04505 Protein ID WP_003253419.1
Coordinates 894442..894723 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCV54_RS04485 890854..891468 - 615 WP_013401779.1 rhomboid family intramembrane serine protease -
BCV54_RS04490 891531..891893 + 363 WP_013877619.1 holo-ACP synthase -
BCV54_RS04495 891975..892988 + 1014 WP_042385737.1 outer membrane lipoprotein-sorting protein -
BCV54_RS04500 893165..894319 + 1155 WP_003253421.1 alanine racemase -
BCV54_RS04505 894442..894723 + 282 WP_003253419.1 hypothetical protein Antitoxin
BCV54_RS04510 894728..895078 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BCV54_RS04515 895289..897475 + 2187 WP_003253404.1 RNA-binding transcriptional accessory protein -
BCV54_RS20570 897470..897583 - 114 WP_013401775.1 cortex morphogenetic protein CmpA -
BCV54_RS04520 897671..898138 + 468 WP_003253403.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T65444 WP_003253417.1 NZ_CP016916:894728-895078 [Parageobacillus thermoglucosidasius]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T65444 NZ_CP016916:894728-895078 [Parageobacillus thermoglucosidasius]
TTGATTGTTAAGCGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCGGAACAAGGAGGCGTTCGTCCGGT
ATTAGTCATTCAAAATGACATTGGAAATCGGTTTAGTCCGACGGTGATTGTGGCGGCGATAACAGCGCAAATCCAAAAAG
CAAAGCTGCCGACACATGTTGAAATTGACGCGAAGCGTTACGGGTTTGAGCGGGATTCTGTTATTCTGCTAGAGCAAATT
CGGACGATTGATAAGCAGCGGCTGACAGACAAAATTACTCACTTGGACGATGAAATGATGGATAAGGTGGATGAAGCGCT
GCAAATTAGTTTAGGACTCATAGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 7.0142

>AT65444 WP_003253419.1 NZ_CP016916:894442-894723 [Parageobacillus thermoglucosidasius]
VSESSATTEIVVRLPQALVTELDVLVKQENGNRNDLIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT65444 NZ_CP016916:894442-894723 [Parageobacillus thermoglucosidasius]
GTGTCGGAATCTAGCGCAACAACGGAAATCGTCGTTCGTTTACCTCAAGCACTAGTAACGGAATTGGATGTGCTTGTTAA
ACAAGAGAACGGCAACCGTAATGATCTCATTTATCAAGCAACTAAAATGTACATTCGCGAGCGAAAAAAACGGCAAATCC
GCGAGGCGATGAGACGCGGTTATATGGAAATGGCGAAAATCAATTTATCCATTGCTTCAGAGGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAGCGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A178U3Z0

References