Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | BrnTA/BrnT_toxin-BrnA |
Location | 2604800..2605337 | Replicon | chromosome |
Accession | NZ_CP016911 | ||
Organism | Burkholderia pseudomallei strain Burk178-Type2 |
Toxin (Protein)
Gene name | brnT | Uniprot ID | Q2T6G2 |
Locus tag | BFR06_RS13470 | Protein ID | WP_004549731.1 |
Coordinates | 2605068..2605337 (-) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | brnA | Uniprot ID | Q63NA3 |
Locus tag | BFR06_RS13465 | Protein ID | WP_004525420.1 |
Coordinates | 2604800..2605084 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BFR06_RS39810 | 2600087..2600272 | - | 186 | WP_024429283.1 | hypothetical protein | - |
BFR06_RS13440 | 2600269..2601984 | - | 1716 | WP_024429282.1 | terminase large subunit | - |
BFR06_RS13445 | 2601988..2602464 | - | 477 | WP_004549538.1 | phage terminase small subunit P27 family | - |
BFR06_RS13450 | 2602602..2602958 | - | 357 | WP_024429281.1 | HNH endonuclease | - |
BFR06_RS13455 | 2603047..2603625 | - | 579 | WP_038738294.1 | hypothetical protein | - |
BFR06_RS13460 | 2603627..2604538 | - | 912 | WP_143281104.1 | hypothetical protein | - |
BFR06_RS13465 | 2604800..2605084 | - | 285 | WP_004525420.1 | BrnA antitoxin family protein | Antitoxin |
BFR06_RS13470 | 2605068..2605337 | - | 270 | WP_004549731.1 | BrnT family toxin | Toxin |
BFR06_RS13475 | 2605386..2605829 | - | 444 | WP_004548453.1 | hypothetical protein | - |
BFR06_RS13480 | 2605826..2606086 | - | 261 | WP_024429361.1 | hypothetical protein | - |
BFR06_RS13485 | 2606062..2606394 | - | 333 | WP_038725178.1 | hypothetical protein | - |
BFR06_RS13490 | 2606424..2606822 | - | 399 | WP_038738296.1 | DUF1364 family protein | - |
BFR06_RS13495 | 2606837..2607184 | - | 348 | WP_043289604.1 | DUF2591 family protein | - |
BFR06_RS13500 | 2607181..2607525 | - | 345 | WP_143297881.1 | winged helix-turn-helix domain-containing protein | - |
BFR06_RS13505 | 2607535..2608071 | - | 537 | WP_024429363.1 | DUF1064 domain-containing protein | - |
BFR06_RS13510 | 2608068..2609060 | - | 993 | WP_038738301.1 | hypothetical protein | - |
BFR06_RS13515 | 2609214..2609474 | - | 261 | WP_004526650.1 | helix-turn-helix domain-containing protein | - |
BFR06_RS13520 | 2609471..2610292 | - | 822 | WP_015967391.1 | chromosome partitioning protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2559920..2628555 | 68635 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10157.46 Da Isoelectric Point: 5.6831
>T65432 WP_004549731.1 NZ_CP016911:c2605337-2605068 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA
Download Length: 270 bp
>T65432 NZ_CP016911:c2605337-2605068 [Burkholderia pseudomallei]
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA
ATGGACATCACCTTTGACCCGACCAAGAACGAAACGAACATTGCCAAGCATGGAGTGTCGTTGGCGCTTGCAGCGCAACT
CGACTGGTCGGACGTGTTGTCCTACGTGGACGACCGACGCGACTACAGTGAAGTGCGCGAAGTCGGGTTCGGTGTGATCG
GCGATCGCCTCTATTGCGTGGTGTTCACGCAGCGCGGCGACTCGATGCACATCATCAGCATGCGTAAGGCGAACAAGCGG
GAGGTCAAGAGCTATGTCGAGCAAGCGTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10697.10 Da Isoelectric Point: 5.8930
>AT65432 WP_004525420.1 NZ_CP016911:c2605084-2604800 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA
Download Length: 285 bp
>AT65432 NZ_CP016911:c2605084-2604800 [Burkholderia pseudomallei]
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAAGCGACGGGCGAAGGTTGGCAGACGCGTATG
AATGATGCGTTGCGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG
ATGTCGAGCAAGCGTAAGATCGTCATGCCGACGGACGAGGAAGACGCGGCAATCAACCGCGGCATCGCGGCCGATCCCGA
CACGTTCGAAGTGCCGGCGGAAGACTTCGCGAAGATGACGCGGCGAGGCAAGCGTGGTCGTCCGCCGCTCGAAGCGCCCA
AGGTGCAATTGACGGTGCGCTATGACGTCGACATTGTCGACGCCTTCAAAGCGACGGGCGAAGGTTGGCAGACGCGTATG
AATGATGCGTTGCGCGAGTGGCTGAGGGAACATCAGCCTGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q2T6G2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0F6L9S8 |