Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1942445..1944040 Replicon plasmid unnamed1
Accession NZ_CP016905
Organism Ralstonia solanacearum strain KACC 10709

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag LBM341_RS23595 Protein ID WP_069079583.1
Coordinates 1942445..1943782 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag LBM341_RS23600 Protein ID WP_016725279.1
Coordinates 1943786..1944040 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBM341_RS23570 1938100..1938840 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
LBM341_RS23575 1938837..1939535 + 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
LBM341_RS23580 1939716..1940279 + 564 WP_080606483.1 RNA 2',3'-cyclic phosphodiesterase -
LBM341_RS23585 1940292..1941020 - 729 WP_011001393.1 DsbA family protein -
LBM341_RS23590 1941246..1942448 - 1203 WP_064047701.1 MFS transporter -
LBM341_RS23595 1942445..1943782 - 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
LBM341_RS23600 1943786..1944040 - 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
LBM341_RS23605 1944144..1944983 - 840 WP_016725278.1 oxaloacetate decarboxylase -
LBM341_RS23610 1945301..1945939 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
LBM341_RS23615 1946007..1946483 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
LBM341_RS23620 1946503..1947054 + 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
LBM341_RS23625 1947051..1947977 + 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - acrB / cheY / cheB / cheW / motA / cyaB / flgC / flgG / fliM / fliG / fliI / adeG 1..2145732 2145732


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T65424 WP_069079583.1 NZ_CP016905:c1943782-1942445 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T65424 NZ_CP016905:c1943782-1942445 [Ralstonia solanacearum]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCATGTCGGCATCTGGACCGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGGTTGGCTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCCATCCGCGAGCGCGTGCGG
CGCCGCTTCGGCCTCGCCTCCACGGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCCCCCACCGGCTACGATCGCATCGACAGCGAGCCGCTCACCGACAGCCAGGTCGACACGCTGC
TGCGCAACCTCACCGCCACGCCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAAACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAGCTGC
TGGCGGCCTGGGGGCTGGAGGTGGCGCGCACCGAGATCGCCCGCTTCGGCGCCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCCACCGGCACGCCCGC
GCACCGCAAATACGAAAACGACGGCGGCCCCGGCATGCGCGCCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTAGCCGCCACCGACGGGCACGCGAAGAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGCTTCCGCATGACGCCGCTGTATGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGGCCGACA
TCCACGTGCGCCACTGGCAGGCGCTGGCGGCGCAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCAGGCGCTGGTCGAG
CGCGTGCCGGCGGGTCTCGAGCGGGTCGAGGCGATCCTGCCGCCCGACTTCTCGGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGGCCGAGCGCTTTCTCAACGAACTGGCGTCCGTCACCCCATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT65424 WP_016725279.1 NZ_CP016905:c1944040-1943786 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT65424 NZ_CP016905:c1944040-1943786 [Ralstonia solanacearum]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGCTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAGTTGGGCGCACTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTACTGCGCATCCTGCACGCGCTCGGCGCGCAGTTGACGCTGCGCACGTCCGCGCCCGCCGGCACCCCCTCCGCCGCG
CCCGCCGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References