Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 24487..25064 Replicon plasmid pGFJ1
Accession NZ_CP016897
Organism Acinetobacter soli strain GFJ2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BEN76_RS16305 Protein ID WP_076033630.1
Coordinates 24487..24675 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BEN76_RS16310 Protein ID WP_076033631.1
Coordinates 24678..25064 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEN76_RS16295 23478..23768 + 291 WP_016165531.1 type II toxin-antitoxin system HigB family toxin -
BEN76_RS16300 23770..24171 + 402 WP_076033629.1 helix-turn-helix domain-containing protein -
BEN76_RS16305 24487..24675 + 189 WP_076033630.1 type II toxin-antitoxin system HicA family toxin Toxin
BEN76_RS16310 24678..25064 + 387 WP_076033631.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BEN76_RS16315 25439..25653 - 215 Protein_16 hypothetical protein -
BEN76_RS16320 25725..26546 - 822 WP_076033632.1 HNH endonuclease -
BEN76_RS16325 26605..26799 - 195 WP_076033633.1 exodeoxyribonuclease VII small subunit -
BEN76_RS16330 26774..28054 - 1281 WP_076033634.1 exodeoxyribonuclease VII large subunit -
BEN76_RS16335 28690..29040 + 351 WP_076033635.1 helix-turn-helix domain-containing protein -
BEN76_RS16340 29044..29577 + 534 WP_016165485.1 ImmA/IrrE family metallo-endopeptidase -
BEN76_RS17435 29733..29885 + 153 WP_016165484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..86373 86373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7367.44 Da        Isoelectric Point: 10.2954

>T65419 WP_076033630.1 NZ_CP016897:24487-24675 [Acinetobacter soli]
MNNKDIIKRLEQEGWYKVGGKGDHEKYKHPEKSGHVVVPHPRKDMPIGTLRNIYKQAGWEWR

Download         Length: 189 bp

>T65419 NZ_CP016897:24487-24675 [Acinetobacter soli]
ATGAACAACAAAGACATTATTAAGCGTCTAGAGCAAGAAGGCTGGTATAAAGTGGGAGGTAAAGGCGACCATGAGAAATA
CAAGCATCCTGAAAAATCTGGTCATGTTGTAGTTCCTCACCCGAGGAAAGACATGCCGATTGGCACTTTACGCAATATTT
ATAAACAGGCTGGTTGGGAGTGGAGGTAA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14592.44 Da        Isoelectric Point: 4.5556

>AT65419 WP_076033631.1 NZ_CP016897:24678-25064 [Acinetobacter soli]
MLYPVYVHKDEDTAYGLTFPDFEGCFSAADEMQDIQRMAQEAVELHFDGEDLKLPKPSSPEQWLGDERFQDGFWLLIDID
TSKINTKSVRINVSMSESLVKRIDAVAKRQHLSRSAFLAKSAELALHD

Download         Length: 387 bp

>AT65419 NZ_CP016897:24678-25064 [Acinetobacter soli]
ATGTTATATCCAGTATATGTTCATAAAGATGAAGATACTGCATACGGCTTAACTTTTCCTGACTTTGAAGGGTGTTTTAG
TGCAGCGGATGAAATGCAAGATATTCAACGCATGGCGCAAGAGGCTGTAGAGCTTCATTTTGATGGTGAAGATTTGAAAT
TACCAAAACCATCAAGCCCTGAACAATGGTTGGGTGATGAGCGATTTCAAGATGGGTTCTGGTTGTTGATTGATATTGAT
ACAAGCAAAATCAATACAAAATCAGTCCGTATCAATGTCAGTATGTCAGAGTCTTTGGTCAAACGTATTGATGCTGTTGC
AAAAAGACAGCATTTAAGTCGATCTGCCTTTTTGGCAAAAAGTGCAGAATTAGCATTACACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References