Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3643223..3644784 Replicon chromosome
Accession NZ_CP016889
Organism Pantoea agglomerans strain C410P1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag BEE12_RS16740 Protein ID WP_069026285.1
Coordinates 3643223..3644536 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BEE12_RS16745 Protein ID WP_022625644.1
Coordinates 3644536..3644784 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEE12_RS16720 3638474..3638809 + 336 WP_069026283.1 gamma-glutamylcyclotransferase -
BEE12_RS16725 3639198..3641243 - 2046 WP_039386591.1 FUSC family protein -
BEE12_RS16730 3641319..3642740 - 1422 WP_069026284.1 M24 family metallopeptidase -
BEE12_RS16735 3642912..3643118 - 207 WP_010244885.1 type II toxin-antitoxin system MqsA family antitoxin -
BEE12_RS16740 3643223..3644536 - 1314 WP_069026285.1 type II toxin-antitoxin system HipA family toxin Toxin
BEE12_RS16745 3644536..3644784 - 249 WP_022625644.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
BEE12_RS16750 3644965..3645401 + 437 Protein_3295 GNAT family N-acetyltransferase -
BEE12_RS16755 3645435..3646229 - 795 WP_069026286.1 inositol monophosphatase -
BEE12_RS16760 3646253..3647314 - 1062 WP_069026287.1 ABC transporter ATP-binding protein -
BEE12_RS16765 3647311..3649535 - 2225 Protein_3298 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-54)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49057.63 Da        Isoelectric Point: 8.8383

>T65400 WP_069026285.1 NZ_CP016889:c3644536-3643223 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILVGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPGFPQHIADAIFSHSLIMLERLRHKE

Download         Length: 1314 bp

>T65400 NZ_CP016889:c3644536-3643223 [Pantoea agglomerans]
ATGCAAAGGCTGATTGCGTGGATGAACGGCGAGCGGGTAGGCGTACTCACCCGGCAGCGAAACGGCGCTCATGAGTTTCA
GTATGATACCGGCTGGCTGAGTAATCCGCTCTCCAGGCCGCTGTCACTTTCAATGCCGTTGCAGGTTAAGGCGATCACCT
CACACGCCGTGATTAACTTCTTCGATAACCTGCTGCCGGATAGCCCATTGATTCGCGACAGAATCGTGGCGCGTTACCAG
ATTAAATCCCGTCAGCCGTTTGATCTGTTGCAGGAAGTGGGACGTGACAGCGTCGGGGCAACCATGCTGCTGCCGCCCGA
TATGCCACTGCCCGCACTGCAGGCCCGCTATGAGGTGCTGGATGAAACCCGGCTCGAAAGCGTGCTGTCGGCCTATCAGT
CAGATATCCCGCTGGGGATGCTGCGTGAAGAGACCGATTTCCGCATCTCGGTCGCGGGGGCGCAGGAGAAAACTGCACTG
CTGCTGACCGATGAAGGCTGGAGCATTCCTGCCGGTGCCACGCCCACCTCGCACATCATTAAGCTGCCGATCGGAGAGAT
TAAACAGCCGGCCGCGACGCTGGATATGCGCGAAAGTGTGGAGAATGAGTATCTCTGTCTGGCGCTGGCCCGTGCACTCG
GTATCGACGTGCCGCAGGCAACGATTATCCGTGCCGGACAGATGCGCGCCCTGGCGGTAGAACGTTTCGACCGCCGCTGG
TCACGCGATAAAACCCGGTTGATCCGCCTGCCGCAGGAGGATTTCTGTCAGGCGCTGGGACTGCCATCTTCAACCAAATA
TGAGTCGGATGGCGGGCCGGGCATTGCGGAGATCATGCAGATACTGGTGGGATCGAGCAACGCCATCGAAGATCGCTATC
GCTTTATGATGTTCCAGGTGTTTCAGTGGCTGATTGGCGCAACCGACGGTCACGCCAAGAACTTCTCACTGTTTATTGAG
CGCGGCGGCAGTTATCGACTGACTCCCTTTTATGATGTGATCTCCGCTTACCCGGTACTGGGCGGCACCGGTCTGAACAA
GCGAGCGCTGAAACTGGCGATGGGTCTGCGTGCCACTAAGGGGAAGAAGACAGAGATCGACAAAATCTTCCCGCGCCATT
TTATCGCCACGGCAAAAAGCGTCAGTTTTGATCGTGACAGTTTGCAGCAGATCTTCGACTTCTTTATTAAGGCCTTTCCC
CAGGCGGTGGTCTCGGTGCGCGATGCTTTGCCGCCAGGTTTCCCGCAGCACATCGCCGACGCCATTTTCAGTCATTCACT
GATTATGCTGGAGCGGCTGCGGCACAAAGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9363.61 Da        Isoelectric Point: 5.0775

>AT65400 WP_022625644.1 NZ_CP016889:c3644784-3644536 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEASAPQLHDED
EW

Download         Length: 249 bp

>AT65400 NZ_CP016889:c3644784-3644536 [Pantoea agglomerans]
ATGATATACAGCCCGCTACAGCTGGCAAACCGGCTAAAGCTCATTCGTCAGCGCAATGGCTGGACCCAGAGTGAGCTGGC
GAAAAAGGTCGGCCTGAAACAGGCTACCATCTCTCACTTTGAAAATGCCCCTGACAGCACCTCGCTGGCAACGCTGTTTA
AGCTGTTACAGTCGCTGGAGCTGAGTCTGGAAGTTCAGGAGAAAGAGGAGGCCAGTGCGCCTCAGTTGCATGATGAGGAT
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References