Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 2587389..2588006 | Replicon | chromosome |
Accession | NZ_CP016889 | ||
Organism | Pantoea agglomerans strain C410P1 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | E0LTU7 |
Locus tag | BEE12_RS11675 | Protein ID | WP_003850458.1 |
Coordinates | 2587389..2587604 (-) | Length | 72 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | E0LTU8 |
Locus tag | BEE12_RS11680 | Protein ID | WP_003850455.1 |
Coordinates | 2587629..2588006 (-) | Length | 126 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BEE12_RS11645 | 2583307..2583645 | + | 339 | WP_003850469.1 | P-II family nitrogen regulator | - |
BEE12_RS11650 | 2583680..2584966 | + | 1287 | WP_010255877.1 | ammonium transporter AmtB | - |
BEE12_RS11655 | 2585017..2585880 | - | 864 | WP_010255880.1 | acyl-CoA thioesterase II | - |
BEE12_RS11660 | 2586071..2586628 | + | 558 | WP_010255881.1 | YbaY family lipoprotein | - |
BEE12_RS11665 | 2586668..2586979 | - | 312 | WP_031592174.1 | MGMT family protein | - |
BEE12_RS11675 | 2587389..2587604 | - | 216 | WP_003850458.1 | hemolysin expression modulator Hha | Toxin |
BEE12_RS11680 | 2587629..2588006 | - | 378 | WP_003850455.1 | Hha toxicity modulator TomB | Antitoxin |
BEE12_RS11685 | 2588154..2588507 | - | 354 | WP_069025895.1 | hypothetical protein | - |
BEE12_RS11690 | 2588849..2589517 | + | 669 | WP_069026576.1 | ABC transporter ATP-binding protein | - |
BEE12_RS11695 | 2589514..2590353 | + | 840 | WP_010255890.1 | metal ABC transporter permease | - |
BEE12_RS11700 | 2590369..2591247 | + | 879 | WP_069025896.1 | metal ABC transporter substrate-binding protein | - |
BEE12_RS23895 | 2591293..2591433 | - | 141 | WP_010255896.1 | type B 50S ribosomal protein L36 | - |
BEE12_RS11705 | 2591445..2591699 | - | 255 | WP_010671219.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 72 a.a. Molecular weight: 8510.90 Da Isoelectric Point: 9.4825
>T65398 WP_003850458.1 NZ_CP016889:c2587604-2587389 [Pantoea agglomerans]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR
Download Length: 216 bp
>T65398 NZ_CP016889:c2587604-2587389 [Pantoea agglomerans]
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGCTGCCGCTCTCTTGATACCCTGGAAAGGGTGAT
TGAAAAAAATAAGTATGAATTACCGGAAGATGAATTAGCGGTATTTTACTCAGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTCTACGATAAAGTCCCGGGTTCAGTATGGAAATTTGTCCGTTAA
ATGAACAAAACCCTGACTAAAACCGATTATTTGATGCGACTGCGGCGCTGCCGCTCTCTTGATACCCTGGAAAGGGTGAT
TGAAAAAAATAAGTATGAATTACCGGAAGATGAATTAGCGGTATTTTACTCAGCAGCTGACCATCGCCTGGCGGAACTGA
CGATGAACAAGCTCTACGATAAAGTCCCGGGTTCAGTATGGAAATTTGTCCGTTAA
Antitoxin
Download Length: 126 a.a. Molecular weight: 14636.25 Da Isoelectric Point: 4.3976
>AT65398 WP_003850455.1 NZ_CP016889:c2588006-2587629 [Pantoea agglomerans]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL
Download Length: 378 bp
>AT65398 NZ_CP016889:c2588006-2587629 [Pantoea agglomerans]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTTTGTGAGAGTCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCATGGCTGGGTTAATGATCCCACTTCTGAAAGCAATCTACAGCTTAACGATTTGATTGAGC
ATATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTATTCAGCAATTATGGTGTCAATAGTCCGGATCTTCAGCGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCGAGCCATTCATTATAG
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACCTTTGTGAGAGTCTGTTTGACGACAGCATGGC
AACATTAACCGACAGCCATCATGGCTGGGTTAATGATCCCACTTCTGAAAGCAATCTACAGCTTAACGATTTGATTGAGC
ATATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGATGAAGCGCTGATTTCGCAAATCGATGAATATCTT
GATGATACTTTTATGCTATTCAGCAATTATGGTGTCAATAGTCCGGATCTTCAGCGGTGGCAACGTTCAGCAAAACGCTT
ATTTAATCTGTTCACTGAAGAGTGCGCTTTTCTCCAGCAACCGAGCCATTCATTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1I5AGC3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1I5AG55 |