65368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2219974..2220662 Replicon chromosome
Accession NZ_CP016888
Organism Mycobacterium tuberculosis strain SCAID 252.0

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag BEE64_RS10365 Protein ID WP_003409958.1
Coordinates 2219974..2220393 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag BEE64_RS10370 Protein ID WP_003409968.1
Coordinates 2220402..2220662 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEE64_RS10345 2215832..2216317 + 486 Protein_2028 class I SAM-dependent methyltransferase -
BEE64_RS10350 2216280..2217725 - 1446 WP_003899115.1 APC family permease -
BEE64_RS10355 2217904..2218590 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
BEE64_RS10360 2218781..2219749 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
BEE64_RS10365 2219974..2220393 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
BEE64_RS10370 2220402..2220662 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BEE64_RS10375 2220805..2222481 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
BEE64_RS10380 2222469..2223122 - 654 WP_003409976.1 cutinase Cfp21 -
BEE64_RS10385 2223237..2223467 + 231 WP_003409980.1 DUF167 domain-containing protein -
BEE64_RS10390 2223552..2224463 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
BEE64_RS10395 2224572..2225171 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T65368 WP_003409958.1 NZ_CP016888:c2220393-2219974 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T65368 NZ_CP016888:c2220393-2219974 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT65368 WP_003409968.1 NZ_CP016888:c2220662-2220402 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT65368 NZ_CP016888:c2220662-2220402 [Mycobacterium tuberculosis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References