Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 23290..23888 Replicon plasmid unnamed
Accession NZ_CP016875
Organism Legionella pneumophila subsp. pneumophila strain FFI329

Toxin (Protein)


Gene name hicA Uniprot ID Q5WRX3
Locus tag BE845_RS14990 Protein ID WP_011212625.1
Coordinates 23290..23487 (+) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q5WRX4
Locus tag BE845_RS14995 Protein ID WP_011212624.1
Coordinates 23484..23888 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BE845_RS15805 19372..19695 + 324 WP_070326930.1 hypothetical protein -
BE845_RS14975 19667..20008 - 342 WP_019350429.1 four helix bundle protein -
BE845_RS14980 20082..21536 - 1455 WP_070322514.1 DUF1566 domain-containing protein -
BE845_RS14985 21547..22296 - 750 WP_070322515.1 porin family protein -
BE845_RS14990 23290..23487 + 198 WP_011212625.1 type II toxin-antitoxin system HicA family toxin Toxin
BE845_RS14995 23484..23888 + 405 WP_011212624.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BE845_RS15000 24459..24782 - 324 WP_011212623.1 hypothetical protein -
BE845_RS15005 24799..27747 - 2949 WP_070322516.1 conjugative relaxase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..68146 68146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7403.75 Da        Isoelectric Point: 10.6519

>T65326 WP_011212625.1 NZ_CP016875:23290-23487 [Legionella pneumophila subsp. pneumophila]
MKSAEIIKIIERDGWVQCHQKGSHCQFKHPTKKGRVTVPHPKKDLPIKTVASIFKQAGINKEDIK

Download         Length: 198 bp

>T65326 NZ_CP016875:23290-23487 [Legionella pneumophila subsp. pneumophila]
ATGAAAAGCGCAGAAATAATAAAAATAATTGAACGCGATGGATGGGTGCAATGTCATCAGAAAGGAAGTCATTGCCAATT
TAAACATCCCACCAAAAAGGGTAGGGTGACAGTACCTCATCCTAAAAAAGATTTACCTATAAAAACAGTGGCCAGTATCT
TTAAACAAGCTGGTATTAATAAGGAGGATATAAAATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15006.00 Da        Isoelectric Point: 4.5129

>AT65326 WP_011212624.1 NZ_CP016875:23484-23888 [Legionella pneumophila subsp. pneumophila]
MRYPVVIHKDEHSDFGVIVPDIPGCYSSGSTYDEALTNVIEAIECHLEGLLIDNEPLPVGTTIDRWINDEEFQGGVWAFV
DIDLSQISGKAKRINITMPERILSLIDLYAKNHAIKNRSSFLADAALSYMESHK

Download         Length: 405 bp

>AT65326 NZ_CP016875:23484-23888 [Legionella pneumophila subsp. pneumophila]
ATGAGATATCCTGTAGTAATACATAAAGACGAACATAGTGATTTTGGTGTAATTGTCCCTGATATTCCTGGATGCTATTC
TTCTGGTAGCACTTATGATGAAGCTTTAACTAACGTAATTGAGGCAATTGAATGCCATTTGGAAGGATTATTAATAGATA
ATGAGCCTCTTCCAGTTGGTACAACAATTGATCGATGGATTAATGATGAAGAGTTTCAGGGCGGGGTATGGGCATTTGTT
GACATTGATTTAAGCCAAATATCGGGTAAAGCAAAACGCATTAATATCACTATGCCAGAGCGCATTTTAAGTCTCATCGA
TCTGTATGCCAAAAACCATGCGATAAAAAATCGTTCCTCCTTTTTGGCCGATGCAGCTCTGAGTTATATGGAAAGTCATA
AGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0VJ23

Antitoxin

Source ID Structure
AlphaFold DB Q5WRX4

References