65307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2065592..2066069 Replicon chromosome
Accession NZ_CP016863
Organism Staphylococcus aureus strain 1625.C01

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag A7Q05_RS11180 Protein ID WP_000052078.1
Coordinates 2065881..2066069 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A7Q05_RS11175 Protein ID WP_001059690.1
Coordinates 2065592..2065852 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7Q05_RS11140 2060985..2061701 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
A7Q05_RS11145 2061849..2062271 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
A7Q05_RS11150 2062670..2063164 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
A7Q05_RS11155 2063319..2063936 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
A7Q05_RS11160 2064009..2064590 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
A7Q05_RS11165 2064815..2065051 + 237 WP_000368687.1 hypothetical protein -
A7Q05_RS11170 2065048..2065251 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A7Q05_RS11175 2065592..2065852 + 261 WP_001059690.1 hypothetical protein Antitoxin
A7Q05_RS11180 2065881..2066069 + 189 WP_000052078.1 hypothetical protein Toxin
A7Q05_RS11185 2066257..2066826 + 570 WP_001106654.1 hypothetical protein -
A7Q05_RS11190 2066914..2067198 + 285 WP_001004395.1 hypothetical protein -
A7Q05_RS11195 2067260..2067478 + 219 WP_000005886.1 hypothetical protein -
A7Q05_RS11200 2067974..2068174 - 201 WP_001059082.1 cold-shock protein -
A7Q05_RS11205 2068531..2069217 - 687 WP_001548082.1 thermonuclease family protein -
A7Q05_RS11210 2069558..2070028 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk / vWbp 2040303..2079741 39438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T65307 WP_000052078.1 NZ_CP016863:2065881-2066069 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T65307 NZ_CP016863:2065881-2066069 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT65307 WP_001059690.1 NZ_CP016863:2065592-2065852 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT65307 NZ_CP016863:2065592-2065852 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References