Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 482859..483336 Replicon chromosome
Accession NZ_CP016861
Organism Staphylococcus aureus strain 1969.N

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag A7U52_RS02835 Protein ID WP_000052078.1
Coordinates 483148..483336 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A7U52_RS02830 Protein ID WP_001059690.1
Coordinates 482859..483119 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U52_RS02795 478252..478968 - 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -
A7U52_RS02800 479116..479538 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
A7U52_RS02805 479937..480431 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
A7U52_RS02810 480586..481203 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
A7U52_RS02815 481276..481857 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
A7U52_RS02820 482082..482318 + 237 WP_000368687.1 hypothetical protein -
A7U52_RS02825 482315..482518 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A7U52_RS02830 482859..483119 + 261 WP_001059690.1 hypothetical protein Antitoxin
A7U52_RS02835 483148..483336 + 189 WP_000052078.1 hypothetical protein Toxin
A7U52_RS02840 483524..484093 + 570 WP_001106654.1 hypothetical protein -
A7U52_RS02845 484181..484465 + 285 WP_001004395.1 hypothetical protein -
A7U52_RS02850 484527..484745 + 219 WP_000005886.1 hypothetical protein -
A7U52_RS02855 485241..485441 - 201 WP_001059082.1 cold-shock protein -
A7U52_RS02860 485798..486484 - 687 WP_001548082.1 thermonuclease family protein -
A7U52_RS02865 486825..487295 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(10-116)

Antitoxin

Helix-turn-helix domain, group 17

(27-75)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T65274 WP_000052078.1 NZ_CP016861:483148-483336 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T65274 NZ_CP016861:483148-483336 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT65274 WP_001059690.1 NZ_CP016861:482859-483119 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT65274 NZ_CP016861:482859-483119 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References