65240

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 556910..557387 Replicon chromosome
Accession NZ_CP016856
Organism Staphylococcus aureus strain 2148.N

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag A7U44_RS02830 Protein ID WP_000052076.1
Coordinates 557199..557387 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A7U44_RS02825 Protein ID WP_001059690.1
Coordinates 556910..557170 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U44_RS02790 552303..553019 - 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -
A7U44_RS02795 553167..553589 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
A7U44_RS02800 553988..554482 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
A7U44_RS02805 554637..555254 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
A7U44_RS02810 555327..555908 - 582 WP_001140693.1 phosphoglycerate mutase family protein -
A7U44_RS02815 556133..556369 + 237 WP_000368687.1 hypothetical protein -
A7U44_RS02820 556366..556569 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A7U44_RS02825 556910..557170 + 261 WP_001059690.1 hypothetical protein Antitoxin
A7U44_RS02830 557199..557387 + 189 WP_000052076.1 hypothetical protein Toxin
A7U44_RS02835 557575..558144 + 570 WP_001106654.1 hypothetical protein -
A7U44_RS02840 558232..558516 + 285 WP_001004395.1 hypothetical protein -
A7U44_RS02845 558578..558796 + 219 WP_000005886.1 hypothetical protein -
A7U44_RS02850 559292..559492 - 201 WP_001059082.1 cold-shock protein -
A7U44_RS02855 559849..560535 - 687 WP_001792695.1 thermonuclease family protein -
A7U44_RS02860 560876..561397 - 522 WP_000824484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T65240 WP_000052076.1 NZ_CP016856:557199-557387 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T65240 NZ_CP016856:557199-557387 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT65240 WP_001059690.1 NZ_CP016856:556910-557170 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT65240 NZ_CP016856:556910-557170 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References