Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1186318..1186795 Replicon chromosome
Accession NZ_CP016855
Organism Staphylococcus aureus strain 5118.N

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag A7U51_RS06555 Protein ID WP_000052078.1
Coordinates 1186607..1186795 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag A7U51_RS06550 Protein ID WP_001059690.1
Coordinates 1186318..1186578 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U51_RS06515 1181711..1182427 - 717 WP_109885745.1 type I 3-dehydroquinate dehydratase -
A7U51_RS06520 1182575..1182997 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
A7U51_RS06525 1183396..1183890 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
A7U51_RS06530 1184045..1184662 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
A7U51_RS06535 1184735..1185316 - 582 WP_001140686.1 phosphoglycerate mutase family protein -
A7U51_RS06540 1185541..1185777 + 237 WP_000368687.1 hypothetical protein -
A7U51_RS06545 1185774..1185977 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
A7U51_RS06550 1186318..1186578 + 261 WP_001059690.1 hypothetical protein Antitoxin
A7U51_RS06555 1186607..1186795 + 189 WP_000052078.1 hypothetical protein Toxin
A7U51_RS06560 1186983..1187552 + 570 WP_001106654.1 hypothetical protein -
A7U51_RS06565 1187640..1187924 + 285 WP_001004395.1 hypothetical protein -
A7U51_RS06570 1187986..1188204 + 219 WP_000005886.1 hypothetical protein -
A7U51_RS06575 1188700..1188900 - 201 WP_001059082.1 cold-shock protein -
A7U51_RS06580 1189257..1189943 - 687 WP_001548082.1 thermonuclease family protein -
A7U51_RS06585 1190284..1190754 - 471 WP_000824472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selq / selk / vWbp 1161030..1200467 39437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T65226 WP_000052078.1 NZ_CP016855:1186607-1186795 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T65226 NZ_CP016855:1186607-1186795 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT65226 WP_001059690.1 NZ_CP016855:1186318-1186578 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT65226 NZ_CP016855:1186318-1186578 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References