65223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 126803..127579 Replicon chromosome
Accession NZ_CP016855
Organism Staphylococcus aureus strain 5118.N

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag A7U51_RS01180 Protein ID WP_000031108.1
Coordinates 127427..127579 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag A7U51_RS01175 Protein ID WP_001251224.1
Coordinates 126803..127402 (+) Length 200 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7U51_RS01155 122719..124176 + 1458 WP_000649907.1 ABC transporter permease subunit -
A7U51_RS01160 124169..124891 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
A7U51_RS01165 125042..126169 + 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
A7U51_RS01170 126174..126644 + 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
A7U51_RS01175 126803..127402 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
A7U51_RS01180 127427..127579 + 153 WP_000031108.1 hypothetical protein Toxin
A7U51_RS01195 128356..128751 + 396 WP_000901021.1 hypothetical protein -
A7U51_RS01200 128947..130332 + 1386 WP_000116224.1 class II fumarate hydratase -
A7U51_RS01205 130795..131616 - 822 WP_000669376.1 RluA family pseudouridine synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T65223 WP_000031108.1 NZ_CP016855:127427-127579 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T65223 NZ_CP016855:127427-127579 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT65223 WP_001251224.1 NZ_CP016855:126803-127402 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT65223 NZ_CP016855:126803-127402 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB X5E2E6


Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References