Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5391499..5392737 Replicon chromosome
Accession NZ_CP016849
Organism Pseudomonas sp. TMW 2.1634

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BFC21_RS25715 Protein ID WP_088379590.1
Coordinates 5391499..5392074 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BFC21_RS25720 Protein ID WP_088379285.1
Coordinates 5392180..5392737 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFC21_RS25690 5387089..5388501 - 1413 WP_120266647.1 DUF2971 domain-containing protein -
BFC21_RS25695 5388556..5388798 - 243 WP_120266648.1 hypothetical protein -
BFC21_RS25700 5388933..5389145 - 213 WP_120266649.1 hypothetical protein -
BFC21_RS25705 5390560..5390787 + 228 WP_095004250.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BFC21_RS25710 5390784..5391158 + 375 WP_120266650.1 type II toxin-antitoxin system VapC family toxin -
BFC21_RS25715 5391499..5392074 - 576 WP_088379590.1 HD domain-containing protein Toxin
BFC21_RS25720 5392180..5392737 - 558 WP_088379285.1 helix-turn-helix domain-containing protein Antitoxin
BFC21_RS25725 5393571..5394716 - 1146 WP_088379286.1 serine hydrolase -
BFC21_RS25730 5394899..5395954 - 1056 WP_088379287.1 fatty acid desaturase -
BFC21_RS25735 5396282..5396623 - 342 WP_016779993.1 hypothetical protein -
BFC21_RS25740 5396793..5397311 + 519 WP_088379288.1 DUF4142 domain-containing protein -
BFC21_RS25745 5397376..5397672 - 297 WP_016779995.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5388556..5396623 8067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(9-183)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21628.68 Da        Isoelectric Point: 4.7641

>T65196 WP_088379590.1 NZ_CP016849:c5392074-5391499 [Pseudomonas sp. TMW 2.1634]
MNIEKIKGRLEFLREAEKLKDVLRSAHTSSGRTESTAEHSWRLCLMAVVFGDYLTGLDRLKMLKMCVIHDLGEAISGDIP
AVNKDSFPNKSEQERNDLILLTNTLDESLKAEILALWDDYENALSPEAVAVKALDKLETMLQHNQGKNPPDFDYEFNLAY
GKKYTDAAPLFEALRNIIDEETKANMLLNPK

Download         Length: 576 bp

>T65196 NZ_CP016849:c5392074-5391499 [Pseudomonas sp. TMW 2.1634]
ATGAACATCGAAAAAATCAAAGGGCGCCTCGAATTTCTACGCGAGGCGGAAAAGCTCAAGGATGTACTTAGAAGCGCGCA
CACTTCTTCCGGGCGAACCGAAAGCACGGCAGAGCACAGCTGGCGCTTATGCCTGATGGCCGTCGTCTTTGGAGATTACC
TGACCGGTCTCGACAGGTTAAAAATGCTCAAGATGTGTGTCATTCACGACTTGGGAGAGGCCATCAGCGGTGACATTCCC
GCGGTCAATAAAGATTCGTTTCCCAACAAGAGCGAGCAAGAGCGGAACGACCTCATTCTCTTGACCAATACTCTGGATGA
ATCATTAAAAGCCGAGATATTGGCACTTTGGGACGACTACGAAAATGCTTTGTCACCAGAGGCGGTAGCCGTCAAGGCGC
TAGATAAGTTGGAAACAATGCTTCAGCACAACCAAGGCAAGAACCCACCGGACTTCGATTACGAATTCAATCTTGCCTAT
GGCAAAAAATACACAGATGCCGCCCCTCTATTCGAGGCGCTTCGCAATATCATCGACGAAGAAACCAAAGCTAATATGCT
TTTGAATCCAAAATAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20556.74 Da        Isoelectric Point: 7.8938

>AT65196 WP_088379285.1 NZ_CP016849:c5392737-5392180 [Pseudomonas sp. TMW 2.1634]
MPDMLLKPSLPGVMLRRWRLLHHVKQSHAAELFSVTQSTISRWESGVLDLDSLAHEKLEKLLAARLTTAADHALGRMVRE
SSRPVHLICDLTHRLLACSSSRAAQFASPVSELLGSSLWRFATPTIISMEADLDRLGWREAFAPPALEFLTGDNHSSIVP
ISQSLCRWTRIPLSDGATTRLVESL

Download         Length: 558 bp

>AT65196 NZ_CP016849:c5392737-5392180 [Pseudomonas sp. TMW 2.1634]
ATGCCTGATATGTTGCTAAAACCATCGTTACCTGGAGTCATGCTCCGGCGATGGCGCCTCTTGCACCACGTCAAACAATC
CCATGCCGCAGAGTTGTTTAGTGTTACCCAATCGACTATCTCTCGCTGGGAAAGTGGCGTACTGGATTTGGATTCCCTCG
CACACGAAAAGCTTGAGAAGTTGCTGGCTGCTCGCCTCACTACAGCCGCAGATCATGCGCTGGGCCGAATGGTTCGTGAA
AGCTCGCGCCCCGTTCATCTCATTTGTGATTTGACGCACCGTTTGCTTGCTTGTTCATCTTCGCGAGCAGCCCAGTTCGC
AAGTCCTGTCAGCGAGCTGCTGGGTAGTTCTTTATGGCGCTTCGCTACGCCAACTATTATTAGCATGGAAGCTGACCTGG
ATAGATTGGGTTGGCGGGAAGCCTTCGCACCCCCAGCGCTGGAATTTCTAACGGGCGACAATCATTCGTCCATTGTTCCG
ATCAGCCAAAGCTTATGTCGCTGGACACGAATCCCCCTTTCGGACGGAGCAACAACACGCCTGGTTGAGTCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References