Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3666894..3667521 Replicon chromosome
Accession NZ_CP016849
Organism Pseudomonas sp. TMW 2.1634

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BFC21_RS17300 Protein ID WP_095004378.1
Coordinates 3667342..3667521 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BFC21_RS17295 Protein ID WP_095004377.1
Coordinates 3666894..3667301 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BFC21_RS17270 3661951..3662361 - 411 WP_016783077.1 type II toxin-antitoxin system HicB family antitoxin -
BFC21_RS17275 3662358..3662555 - 198 WP_081481088.1 type II toxin-antitoxin system HicA family toxin -
BFC21_RS17280 3662798..3663298 + 501 WP_120266392.1 sigma-70 family RNA polymerase sigma factor -
BFC21_RS17285 3663298..3664245 + 948 WP_120266393.1 FecR domain-containing protein -
BFC21_RS17290 3664358..3666796 + 2439 WP_088378487.1 TonB-dependent siderophore receptor -
BFC21_RS17295 3666894..3667301 - 408 WP_095004377.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BFC21_RS17300 3667342..3667521 - 180 WP_095004378.1 type II toxin-antitoxin system HicA family toxin Toxin
BFC21_RS17305 3667755..3669095 + 1341 WP_088378488.1 gluconate:H+ symporter -
BFC21_RS17310 3669139..3670485 + 1347 WP_095004380.1 D-serine ammonia-lyase -
BFC21_RS17315 3670569..3671522 + 954 WP_120266394.1 DNA-binding transcriptional regulator DsdC -
BFC21_RS17320 3671529..3671834 - 306 WP_016783069.1 XRE family transcriptional regulator -
BFC21_RS17325 3671827..3672192 - 366 WP_088378491.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.9432

>T65194 WP_095004378.1 NZ_CP016849:c3667521-3667342 [Pseudomonas sp. TMW 2.1634]
MNSRQLITALEADGWYLVRSKGSHHHFKHPTKPGLVTIPHPKKDLLTKTINSILKQAQL

Download         Length: 180 bp

>T65194 NZ_CP016849:c3667521-3667342 [Pseudomonas sp. TMW 2.1634]
TTGAATAGCCGACAGCTGATAACCGCACTGGAAGCTGACGGTTGGTATCTGGTACGGAGCAAGGGAAGTCATCACCACTT
CAAACACCCGACAAAGCCGGGGCTGGTAACGATTCCTCACCCGAAGAAAGATTTACTGACCAAAACGATCAACAGTATTT
TGAAGCAAGCTCAGCTTTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14808.85 Da        Isoelectric Point: 4.5221

>AT65194 WP_095004377.1 NZ_CP016849:c3667301-3666894 [Pseudomonas sp. TMW 2.1634]
MLYPIAIRPGDEQHAWGVDVPDIPGCFSAGEDLDDAMAMAREAIEGHLEMLAEDCSRIPVATPVSAHVSNPEYEGCIWAL
VDIDITRYLGKAEKLNITLPGNLLNRIDEYVKHHPEQKSRSGFLASAALKVLQQA

Download         Length: 408 bp

>AT65194 NZ_CP016849:c3667301-3666894 [Pseudomonas sp. TMW 2.1634]
ATGCTTTACCCAATAGCCATTCGCCCTGGCGATGAACAACATGCCTGGGGTGTAGACGTGCCGGATATTCCCGGGTGCTT
CTCTGCGGGGGAGGATCTTGACGACGCGATGGCCATGGCACGCGAAGCCATTGAAGGGCATCTGGAGATGTTGGCAGAGG
ATTGCAGCCGGATTCCTGTGGCAACCCCGGTAAGCGCTCATGTCTCCAACCCGGAGTATGAGGGCTGCATCTGGGCATTG
GTCGATATCGATATCACCAGATACCTCGGAAAGGCGGAAAAGCTGAATATTACCTTGCCCGGGAACCTGCTGAATCGGAT
CGATGAGTATGTGAAACATCATCCTGAGCAAAAGAGCCGTTCAGGATTTCTGGCCTCGGCAGCATTGAAGGTTCTGCAAC
AAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References