Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2004009..2004679 Replicon chromosome
Accession NZ_CP016833
Organism Xanthomonas fragariae isolate Fap29

Toxin (Protein)


Gene name vapC Uniprot ID A0A1Y6H9H7
Locus tag BER93_RS09160 Protein ID WP_002805728.1
Coordinates 2004260..2004679 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1Y6HLT7
Locus tag BER93_RS09155 Protein ID WP_002805732.1
Coordinates 2004009..2004263 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BER93_RS09130 1999594..2000598 - 1005 WP_002805744.1 hypothetical protein -
BER93_RS09135 2000680..2000913 + 234 WP_002805742.1 hypothetical protein -
BER93_RS09140 2000917..2001795 + 879 WP_002805739.1 helicase RepA family protein -
BER93_RS09145 2001767..2002654 + 888 WP_172404498.1 replication protein C -
BER93_RS09150 2003316..2003597 + 282 WP_002805735.1 TraK family protein -
BER93_RS09155 2004009..2004263 + 255 WP_002805732.1 Arc family DNA-binding protein Antitoxin
BER93_RS09160 2004260..2004679 + 420 WP_002805728.1 type II toxin-antitoxin system VapC family toxin Toxin
BER93_RS09165 2004836..2005450 + 615 WP_040762517.1 P-type conjugative transfer protein TrbJ -
BER93_RS09170 2005536..2005778 + 243 Protein_1837 transposase -
BER93_RS09175 2005896..2007263 + 1368 WP_065975195.1 IS5 family transposase -
BER93_RS09180 2007286..2008191 + 906 Protein_1839 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1989323..2006959 17636
- flank IS/Tn - - 1998183..1999520 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14879.07 Da        Isoelectric Point: 5.1890

>T65187 WP_002805728.1 NZ_CP016833:2004260-2004679 [Xanthomonas fragariae]
MIVLDTNVVSEAIKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T65187 NZ_CP016833:2004260-2004679 [Xanthomonas fragariae]
ATGATTGTCTTGGATACGAATGTAGTCTCCGAGGCGATAAAACCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTTGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAACTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCGGCTCGCCATTATGCCGAGCTGGCGGTGAAGGCCCGCACAGCCGGGAAGGGTTTTCCAACACCTGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTCGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9522.89 Da        Isoelectric Point: 5.7425

>AT65187 WP_002805732.1 NZ_CP016833:2004009-2004263 [Xanthomonas fragariae]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRQVVLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT65187 NZ_CP016833:2004009-2004263 [Xanthomonas fragariae]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGACGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTCCGCGAGATTCTGGAGAGTGCAGTTAAGTCAGAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCAAGTAGTGCTGACAAACGATGATTTCGCAGTGTTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6H9H7

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y6HLT7

References