Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2004008..2004678 Replicon chromosome
Accession NZ_CP016830
Organism Xanthomonas fragariae isolate Fap21

Toxin (Protein)


Gene name vapC Uniprot ID A0A1Y6H9H7
Locus tag BER92_RS09140 Protein ID WP_002805728.1
Coordinates 2004259..2004678 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1Y6HLT7
Locus tag BER92_RS09135 Protein ID WP_002805732.1
Coordinates 2004008..2004262 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BER92_RS09110 1999593..2000597 - 1005 WP_002805744.1 hypothetical protein -
BER92_RS09115 2000679..2000912 + 234 WP_002805742.1 hypothetical protein -
BER92_RS09120 2000916..2001794 + 879 WP_002805739.1 helicase RepA family protein -
BER92_RS09125 2001766..2002653 + 888 WP_172404498.1 replication protein C -
BER92_RS09130 2003315..2003596 + 282 WP_002805735.1 TraK family protein -
BER92_RS09135 2004008..2004262 + 255 WP_002805732.1 Arc family DNA-binding protein Antitoxin
BER92_RS09140 2004259..2004678 + 420 WP_002805728.1 type II toxin-antitoxin system VapC family toxin Toxin
BER92_RS09145 2004835..2005449 + 615 WP_040762517.1 P-type conjugative transfer protein TrbJ -
BER92_RS09150 2005535..2005777 + 243 Protein_1830 transposase -
BER92_RS09155 2005895..2007262 + 1368 WP_065975195.1 IS5 family transposase -
BER92_RS09160 2007285..2008190 + 906 Protein_1832 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1989322..2006958 17636
- flank IS/Tn - - 1998182..1999519 1337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14879.07 Da        Isoelectric Point: 5.1890

>T65183 WP_002805728.1 NZ_CP016830:2004259-2004678 [Xanthomonas fragariae]
MIVLDTNVVSEAIKPEPNPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFGERVLMFDTE
AARHYAELAVKARTAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHQ

Download         Length: 420 bp

>T65183 NZ_CP016830:2004259-2004678 [Xanthomonas fragariae]
ATGATTGTCTTGGATACGAATGTAGTCTCCGAGGCGATAAAACCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTTGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAACTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCGGCTCGCCATTATGCCGAGCTGGCGGTGAAGGCCCGCACAGCCGGGAAGGGTTTTCCAACACCTGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTCGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9522.89 Da        Isoelectric Point: 5.7425

>AT65183 WP_002805732.1 NZ_CP016830:2004008-2004262 [Xanthomonas fragariae]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSEKRIRMGDALAELGRQVVLTNDDFAVLDQVRDKVPAEP
MRFE

Download         Length: 255 bp

>AT65183 NZ_CP016830:2004008-2004262 [Xanthomonas fragariae]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGACGAGGTGCATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTCCGCGAGATTCTGGAGAGTGCAGTTAAGTCAGAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCAAGTAGTGCTGACAAACGATGATTTCGCAGTGTTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6H9H7

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y6HLT7

References