Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4010440..4011392 Replicon chromosome
Accession NZ_CP016819
Organism Rhodococcus sp. p52

Toxin (Protein)


Gene name pezT Uniprot ID A0A1B2UGP8
Locus tag IM25_RS18470 Protein ID WP_065996245.1
Coordinates 4010440..4011009 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1B2UGQ9
Locus tag IM25_RS18475 Protein ID WP_033098294.1
Coordinates 4011006..4011392 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM25_RS18470 4010440..4011009 - 570 WP_065996245.1 zeta toxin family protein Toxin
IM25_RS18475 4011006..4011392 - 387 WP_033098294.1 hypothetical protein Antitoxin
IM25_RS18480 4011599..4012669 + 1071 WP_198162509.1 class I SAM-dependent methyltransferase -
IM25_RS18485 4012739..4013104 + 366 WP_024101068.1 HNH endonuclease -
IM25_RS18490 4013121..4013621 - 501 WP_157126970.1 hypothetical protein -
IM25_RS18495 4014728..4015660 - 933 WP_033098296.1 TAXI family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-68)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20510.63 Da        Isoelectric Point: 10.6895

>T65157 WP_065996245.1 NZ_CP016819:c4011009-4010440 [Rhodococcus sp. p52]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGGPVGAVRWPGWAPAALTGLG

Download         Length: 570 bp

>T65157 NZ_CP016819:c4011009-4010440 [Rhodococcus sp. p52]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAGCTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCACCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATCCGGGCGCGTTATC
GGCGGTTGTGGCCGCTGGTGACCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGGGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14015.45 Da        Isoelectric Point: 4.4920

>AT65157 WP_033098294.1 NZ_CP016819:c4011392-4011006 [Rhodococcus sp. p52]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVREALAGTQELSELTAAEGRLFDAEI
DARLADGLARTDYAEILAARGVTTVVLDDEGRLVEQRPDGSRQVLDDA

Download         Length: 387 bp

>AT65157 NZ_CP016819:c4011392-4011006 [Rhodococcus sp. p52]
ATGACGTCATCCACCGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCGCGAGGCGCTGGCCGGGACACAAGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGATTCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCAGGTGCTCGACGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B2UGP8

Antitoxin

Source ID Structure
AlphaFold DB A0A1B2UGQ9

References