65155

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1329734..1330233 Replicon chromosome
Accession NZ_CP016819
Organism Rhodococcus sp. p52

Toxin (Protein)


Gene name relE Uniprot ID A0A1B2UAV2
Locus tag IM25_RS06110 Protein ID WP_033098481.1
Coordinates 1329734..1329988 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1B2UAS3
Locus tag IM25_RS06115 Protein ID WP_033098482.1
Coordinates 1329985..1330233 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IM25_RS06080 1325168..1326337 - 1170 WP_065995865.1 acyl-CoA dehydrogenase family protein -
IM25_RS06085 1326440..1327066 + 627 WP_065995866.1 TetR family transcriptional regulator -
IM25_RS06095 1327443..1327685 - 243 WP_082331778.1 transposase -
IM25_RS06100 1327999..1328955 - 957 WP_019290518.1 Lsr2 family protein -
IM25_RS26380 1329112..1329633 + 522 WP_198162539.1 hypothetical protein -
IM25_RS06110 1329734..1329988 - 255 WP_033098481.1 Txe/YoeB family addiction module toxin Toxin
IM25_RS06115 1329985..1330233 - 249 WP_033098482.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IM25_RS06120 1330637..1331431 + 795 WP_065995867.1 LLM class F420-dependent oxidoreductase -
IM25_RS06125 1331492..1332724 + 1233 WP_019290511.1 alpha/beta fold hydrolase -
IM25_RS06130 1332853..1334931 + 2079 WP_065995868.1 PhoX family phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10009.26 Da        Isoelectric Point: 6.2185

>T65155 WP_033098481.1 NZ_CP016819:c1329988-1329734 [Rhodococcus sp. p52]
VNITFTDEAWDDYQFWISTDRKQLERVNELIRDCQRDPYSGIGKPERLSHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Download         Length: 255 bp

>T65155 NZ_CP016819:c1329988-1329734 [Rhodococcus sp. p52]
GTGAACATCACCTTCACCGACGAAGCCTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAGCAGCTCGAGCGTGT
CAACGAGCTGATCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGTCATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9278.54 Da        Isoelectric Point: 6.4662

>AT65155 WP_033098482.1 NZ_CP016819:c1330233-1329985 [Rhodococcus sp. p52]
MAAITATEARRNFFPLVEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEHTEREL
IE

Download         Length: 249 bp

>AT65155 NZ_CP016819:c1330233-1329985 [Rhodococcus sp. p52]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAGAAACTTCTTTCCGCTGGTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAACACACCGAAAGGGAACTC
ATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B2UAV2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B2UAS3

References