Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1175103..1175667 Replicon chromosome
Accession NZ_CP016818
Organism Mycobacterium avium subsp. hominissuis strain HP17

Toxin (Protein)


Gene name vapC Uniprot ID A0A2A2ZLT9
Locus tag BEP52_RS05890 Protein ID WP_023868517.1
Coordinates 1175296..1175667 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BEP52_RS05885 Protein ID WP_011724021.1
Coordinates 1175103..1175309 (+) Length 69 a.a.

Genomic Context

BEP52_RS05865BEP52_RS05875BEP52_RS05880BEP52_RS05885BEP52_RS05890BEP52_RS05895BEP52_RS05905BEP52_RS05910BEP52_RS05915BEP52_RS05920BEP52_RS05925BEP52_RS05930BEP52_RS05870BEP52_RS05900
Location: 1170357..1171355 (999 bp)
Type: Others
Protein ID: WP_023868514.1
Location: 1172718..1173791 (1074 bp)
Type: Others
Protein ID: WP_044543554.1
Location: 1173991..1174935 (945 bp)
Type: Others
Protein ID: WP_084250736.1
Location: 1175103..1175309 (207 bp)
Type: Antitoxin
Protein ID: WP_011724021.1
Location: 1175296..1175667 (372 bp)
Type: Toxin
Protein ID: WP_023868517.1
Location: 1175767..1176207 (441 bp)
Type: Others
Protein ID: WP_003875392.1
Location: 1177085..1177690 (606 bp)
Type: Others
Protein ID: WP_095975041.1
Location: 1177792..1178190 (399 bp)
Type: Others
Protein ID: WP_044543557.1
Location: 1178259..1178642 (384 bp)
Type: Others
Protein ID: WP_011724026.1
Location: 1178712..1179065 (354 bp)
Type: Others
Protein ID: WP_023865350.1
Location: 1179222..1179830 (609 bp)
Type: Others
Protein ID: WP_080772802.1
Location: 1180196..1180519 (324 bp)
Type: Others
Protein ID: WP_044543559.1
Location: 1171379..1172587 (1209 bp)
Type: Others
Protein ID: WP_179145049.1
Location: 1176273..1177010 (738 bp)
Type: Others
Protein ID: WP_044543556.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BEP52_RS058651170357..1171355+999WP_023868514.14-hydroxy-3-methylbut-2-enyl diphosphate reductase-
BEP52_RS058701171379..1172587-1209WP_179145049.1hypothetical protein-
BEP52_RS058751172718..1173791+1074WP_044543554.1redox-regulated ATPase YchF-
BEP52_RS058801173991..1174935+945WP_084250736.1HNH endonuclease-
BEP52_RS058851175103..1175309+207WP_011724021.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
BEP52_RS058901175296..1175667+372WP_023868517.1type II toxin-antitoxin system VapC family toxinToxin
BEP52_RS058951175767..1176207+441WP_003875392.1nitroreductase family deazaflavin-dependent oxidoreductase-
BEP52_RS059001176273..1177010-738WP_044543556.1SDR family oxidoreductase-
BEP52_RS059051177085..1177690+606WP_095975041.1TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator-
BEP52_RS059101177792..1178190+399WP_044543557.1VOC family protein-
BEP52_RS059151178259..1178642+384WP_011724026.1hypothetical protein-
BEP52_RS059201178712..1179065+354WP_023865350.1hypothetical protein-
BEP52_RS059251179222..1179830+609WP_080772802.1glycoside hydrolase-
BEP52_RS059301180196..1180519+324WP_044543559.1antibiotic biosynthesis monooxygenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13754.08 Da        Isoelectric Point: 6.6032

>T65153 WP_023868517.1 NZ_CP016818:1175296-1175667 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVESHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Download         Length: 372 bp

>T65153 NZ_CP016818:1175296-1175667 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAAAGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7261.25 Da        Isoelectric Point: 11.0634

>AT65153 WP_011724021.1 NZ_CP016818:1175103-1175309 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Download         Length: 207 bp

>AT65153 NZ_CP016818:1175103-1175309 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2A2ZLT9

Antitoxin

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Source
ID
Structure
No matching records found

References