Detailed information of TA system TA065152

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 875759..876412
• Replicon: chromosome
• Accession: NZ_CP016818
• Organism: Mycobacterium avium subsp. hominissuis strain HP17

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: BEP52_RS04415
• Protein ID: WP_003872880.1
• Coordinates: 875951..876412 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: A0A808C2V3
• Locus tag: BEP52_RS04410
• Protein ID: WP_023869662.1
• Coordinates: 875759..875947 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BEP52_RS04400	871741..873327	+	1587	WP_023869664.1	serine hydrolase	-
BEP52_RS04405	873324..875696	+	2373	WP_023869663.1	cation-translocating P-type ATPase	-
BEP52_RS04410	875759..875947	+	189	WP_023869662.1	antitoxin	Antitoxin
BEP52_RS04415	875951..876412	+	462	WP_003872880.1	SRPBCC family protein	Toxin
BEP52_RS04420	876481..876915	+	435	WP_023869661.1	hypothetical protein	-
BEP52_RS04425	876920..877396	-	477	WP_023869660.1	VOC family protein	-
BEP52_RS04430	878361..879944	+	1584	WP_003872878.1	DUF4185 domain-containing protein	-
BEP52_RS04435	879991..880377	+	387	WP_023869659.1	hypothetical protein	-
BEP52_RS04440	880412..880630	-	219	WP_023869658.1	hypothetical protein	-
BEP52_RS04445	880821..881395	-	575	Protein_871	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (2-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16626.19 Da
• Isoelectric Point: 9.5654

>T65152 WP_003872880.1 NZ_CP016818:875951-876412 [Mycobacterium avium subsp. hominissuis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Nucleotide

• Length: 462 bp

>T65152 NZ_CP016818:875951-876412 [Mycobacterium avium subsp. hominissuis]
GTGGCCAAGCTATCCGGATCCATCGATGTTCCGCTGCCGCCCGAGGTGGCCTGGCAGCATGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6729.36 Da
• Isoelectric Point: 4.4702

>AT65152 WP_023869662.1 NZ_CP016818:875759-875947 [Mycobacterium avium subsp. hominissuis]
MGFLDKAKDLLSQNADKVEIAIDKAGEFVDDKTQGKYSDTIHQVQEQAKKATGSTETGDQQG

Nucleotide

• Length: 189 bp

>AT65152 NZ_CP016818:875759-875947 [Mycobacterium avium subsp. hominissuis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATTGCCATCGACAAGGCCGGCGA
GTTCGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCA
GCACCGAGACCGGCGACCAGCAGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A808C2V3