Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4541933..4542590 Replicon chromosome
Accession NZ_CP016814
Organism Klebsiella pneumoniae strain ED23

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BCV49_RS22305 Protein ID WP_002916310.1
Coordinates 4541933..4542343 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BCV49_RS22310 Protein ID WP_002916312.1
Coordinates 4542324..4542590 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCV49_RS22285 4537933..4539666 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
BCV49_RS22290 4539672..4540385 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BCV49_RS22295 4540408..4541304 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
BCV49_RS22300 4541405..4541926 + 522 WP_002916308.1 flavodoxin FldB -
BCV49_RS22305 4541933..4542343 - 411 WP_002916310.1 protein YgfX Toxin
BCV49_RS22310 4542324..4542590 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BCV49_RS22315 4542836..4543819 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
BCV49_RS22320 4543918..4544577 - 660 WP_002916317.1 hemolysin III family protein -
BCV49_RS22325 4544741..4545052 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
BCV49_RS22330 4545102..4545830 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
BCV49_RS22335 4545949..4547382 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T65146 WP_002916310.1 NZ_CP016814:c4542343-4541933 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T65146 NZ_CP016814:c4542343-4541933 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT65146 WP_002916312.1 NZ_CP016814:c4542590-4542324 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT65146 NZ_CP016814:c4542590-4542324 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References