Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4580269..4580926 Replicon chromosome
Accession NZ_CP016813
Organism Klebsiella pneumoniae strain ED2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BCV48_RS22095 Protein ID WP_002916310.1
Coordinates 4580269..4580679 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BCV48_RS22100 Protein ID WP_002916312.1
Coordinates 4580660..4580926 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCV48_RS22075 4576269..4578002 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
BCV48_RS22080 4578008..4578721 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BCV48_RS22085 4578744..4579640 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
BCV48_RS22090 4579741..4580262 + 522 WP_002916308.1 flavodoxin FldB -
BCV48_RS22095 4580269..4580679 - 411 WP_002916310.1 protein YgfX Toxin
BCV48_RS22100 4580660..4580926 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BCV48_RS22105 4581172..4582155 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
BCV48_RS22110 4582254..4582913 - 660 WP_002916317.1 hemolysin III family protein -
BCV48_RS22115 4583077..4583388 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
BCV48_RS22120 4583438..4584166 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
BCV48_RS22125 4584285..4585718 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T65130 WP_002916310.1 NZ_CP016813:c4580679-4580269 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T65130 NZ_CP016813:c4580679-4580269 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT65130 WP_002916312.1 NZ_CP016813:c4580926-4580660 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT65130 NZ_CP016813:c4580926-4580660 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References