Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 512767..513283 Replicon chromosome
Accession NZ_CP016813
Organism Klebsiella pneumoniae strain ED2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag BCV48_RS02575 Protein ID WP_004178374.1
Coordinates 512999..513283 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag BCV48_RS02570 Protein ID WP_002886901.1
Coordinates 512767..513009 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCV48_RS02555 508795..509535 + 741 WP_002886899.1 KDGP aldolase family protein -
BCV48_RS02560 509602..510756 + 1155 WP_012737230.1 lactonase family protein -
BCV48_RS02565 510779..512689 + 1911 WP_012737231.1 BglG family transcription antiterminator -
BCV48_RS02570 512767..513009 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BCV48_RS02575 512999..513283 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BCV48_RS02580 513287..513751 - 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BCV48_RS02585 514080..516218 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
BCV48_RS02595 516575..517318 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
BCV48_RS28340 517321..517494 - 174 WP_041169004.1 hypothetical protein -
BCV48_RS02605 517579..517887 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T65118 WP_004178374.1 NZ_CP016813:512999-513283 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T65118 NZ_CP016813:512999-513283 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT65118 WP_002886901.1 NZ_CP016813:512767-513009 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT65118 NZ_CP016813:512767-513009 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References