Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2955283..2955902 Replicon chromosome
Accession NZ_CP016811
Organism Klebsiella pneumoniae strain DHQP1002001

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag A8C02_RS16395 Protein ID WP_002892050.1
Coordinates 2955684..2955902 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag A8C02_RS16390 Protein ID WP_002892066.1
Coordinates 2955283..2955657 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8C02_RS16380 2950435..2951628 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A8C02_RS16385 2951651..2954797 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
A8C02_RS16390 2955283..2955657 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
A8C02_RS16395 2955684..2955902 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
A8C02_RS16400 2956061..2956627 + 567 WP_002892030.1 maltose O-acetyltransferase -
A8C02_RS31295 2956599..2956739 - 141 WP_004147370.1 hypothetical protein -
A8C02_RS16410 2956760..2957230 + 471 WP_002892026.1 YlaC family protein -
A8C02_RS16415 2957205..2958656 - 1452 WP_021313732.1 PLP-dependent aminotransferase family protein -
A8C02_RS16420 2958757..2959455 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
A8C02_RS16425 2959452..2959592 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
A8C02_RS16430 2959592..2959855 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T65109 WP_002892050.1 NZ_CP016811:2955684-2955902 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T65109 NZ_CP016811:2955684-2955902 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT65109 WP_002892066.1 NZ_CP016811:2955283-2955657 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT65109 NZ_CP016811:2955283-2955657 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References