Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3106089..3106659 Replicon chromosome
Accession NZ_CP016794
Organism Mycobacterium tuberculosis strain SCAID 320.0

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag BEE65_RS14775 Protein ID WP_003414166.1
Coordinates 3106089..3106445 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag BEE65_RS14780 Protein ID WP_003901465.1
Coordinates 3106429..3106659 (-) Length 77 a.a.

Genomic Context

BEE65_RS14765BEE65_RS14770BEE65_RS22200BEE65_RS14800BEE65_RS14805BEE65_RS14810BEE65_RS14815BEE65_RS14820BEE65_RS14755BEE65_RS14760BEE65_RS14775BEE65_RS14780BEE65_RS14785BEE65_RS22205
Location: 3103732..3104319 (588 bp)
Type: Others
Protein ID: WP_003914429.1
Location: 3104338..3105987 (1650 bp)
Type: Others
Protein ID: WP_003899485.1
Location: 3107936..3108211 (276 bp)
Type: Others
Protein ID: WP_003911993.1
Location: 3108789..3109193 (405 bp)
Type: Others
Protein ID: WP_003414181.1
Location: 3109190..3109381 (192 bp)
Type: Others
Protein ID: WP_003414184.1
Location: 3109445..3110734 (1290 bp)
Type: Others
Protein ID: Protein_2899
Location: 3110968..3111225 (258 bp)
Type: Others
Protein ID: WP_003899489.1
Location: 3111330..3111641 (312 bp)
Type: Others
Protein ID: WP_003414190.1
Location: 3101541..3103229 (1689 bp)
Type: Others
Protein ID: WP_003414155.1
Location: 3103233..3103559 (327 bp)
Type: Others
Protein ID: WP_003414157.1
Location: 3106089..3106445 (357 bp)
Type: Toxin
Protein ID: WP_003414166.1
Location: 3106429..3106659 (231 bp)
Type: Antitoxin
Protein ID: WP_003901465.1
Location: 3106702..3107745 (1044 bp)
Type: Others
Protein ID: WP_003414172.1
Location: 3108387..3108641 (255 bp)
Type: Others
Protein ID: WP_003917684.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BEE65_RS147553101541..3103229-1689WP_003414155.1alpha/beta hydrolase family protein-
BEE65_RS147603103233..3103559-327WP_003414157.1hypothetical protein-
BEE65_RS147653103732..3104319+588WP_003914429.1DUF3558 family protein-
BEE65_RS147703104338..3105987+1650WP_003899485.1CocE/NonD family hydrolase-
BEE65_RS147753106089..3106445-357WP_003414166.1type II toxin-antitoxin system toxin endoribonuclease MazF9Toxin
BEE65_RS147803106429..3106659-231WP_003901465.1antitoxin MazEAntitoxin
BEE65_RS147853106702..3107745-1044WP_003414172.1DUF2293 domain-containing protein-
BEE65_RS222003107936..3108211+276WP_003911993.1DUF1778 domain-containing protein-
BEE65_RS222053108387..3108641-255WP_003917684.1hypothetical protein-
BEE65_RS148003108789..3109193+405WP_003414181.1hypothetical protein-
BEE65_RS148053109190..3109381+192WP_003414184.1hypothetical protein-
BEE65_RS148103109445..3110734+1290Protein_2899transposase family protein-
BEE65_RS148153110968..3111225+258WP_003899489.1hypothetical protein-
BEE65_RS148203111330..3111641+312WP_003414190.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T65083 WP_003414166.1 NZ_CP016794:c3106445-3106089 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T65083 NZ_CP016794:c3106445-3106089 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT65083 WP_003901465.1 NZ_CP016794:c3106659-3106429 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT65083 NZ_CP016794:c3106659-3106429 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6L2A
PDB5HJZ
PDB6KYT
PDB6L29
PDB7DU5
PDB6KYS

Antitoxin

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Source
ID
Structure
PDB7DU5
PDB6KYT
AlphaFold DBA0A7U4FBW3

References