Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2865850..2866487 Replicon chromosome
Accession NZ_CP016794
Organism Mycobacterium tuberculosis strain SCAID 320.0

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag BEE65_RS13480 Protein ID WP_003413180.1
Coordinates 2865850..2866245 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag BEE65_RS13485 Protein ID WP_003413183.1
Coordinates 2866242..2866487 (-) Length 82 a.a.

Genomic Context

BEE65_RS13445BEE65_RS13450BEE65_RS13455BEE65_RS22185BEE65_RS13460BEE65_RS13465BEE65_RS13470BEE65_RS13475BEE65_RS13480BEE65_RS13485BEE65_RS13490BEE65_RS13495BEE65_RS13500BEE65_RS13505
Location: 2861254..2862465 (1212 bp)
Type: Others
Protein ID: WP_003900845.1
Location: 2862592..2863251 (660 bp)
Type: Others
Protein ID: WP_003902296.1
Location: 2863248..2863910 (663 bp)
Type: Others
Protein ID: WP_003905878.1
Location: 2863907..2864184 (278 bp)
Type: Others
Protein ID: Protein_2629
Location: 2864277..2864690 (414 bp)
Type: Others
Protein ID: WP_003413164.1
Location: 2864729..2864986 (258 bp)
Type: Others
Protein ID: WP_003413167.1
Location: 2864983..2865360 (378 bp)
Type: Others
Protein ID: WP_003413174.1
Location: 2865376..2865750 (375 bp)
Type: Others
Protein ID: WP_003413177.1
Location: 2865850..2866245 (396 bp)
Type: Toxin
Protein ID: WP_003413180.1
Location: 2866242..2866487 (246 bp)
Type: Antitoxin
Protein ID: WP_003413183.1
Location: 2866898..2867317 (420 bp)
Type: Others
Protein ID: WP_003413190.1
Location: 2867329..2868138 (810 bp)
Type: Others
Protein ID: WP_003413193.1
Location: 2868135..2869388 (1254 bp)
Type: Others
Protein ID: WP_003413196.1
Location: 2869381..2869893 (513 bp)
Type: Others
Protein ID: WP_003413197.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BEE65_RS134452861254..2862465+1212WP_003900845.1alpha/beta hydrolase family protein-
BEE65_RS134502862592..2863251+660WP_003902296.1hypothetical protein-
BEE65_RS134552863248..2863910+663WP_003905878.1hypothetical protein-
BEE65_RS221852863907..2864184+278Protein_2629type II toxin-antitoxin system VapB family antitoxin-
BEE65_RS134602864277..2864690+414WP_003413164.1PIN domain nuclease-
BEE65_RS134652864729..2864986+258WP_003413167.1ribbon-helix-helix domain-containing protein-
BEE65_RS134702864983..2865360+378WP_003413174.1type II toxin-antitoxin system VapC family toxin-
BEE65_RS134752865376..2865750-375WP_003413177.1hypothetical protein-
BEE65_RS134802865850..2866245-396WP_003413180.1type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20Toxin
BEE65_RS134852866242..2866487-246WP_003413183.1type II toxin-antitoxin system antitoxin VapB20Antitoxin
BEE65_RS134902866898..2867317-420WP_003413190.1A24 family peptidase-
BEE65_RS134952867329..2868138-810WP_003413193.1shikimate dehydrogenase-
BEE65_RS135002868135..2869388-1254WP_003413196.1endolytic transglycosylase MltG-
BEE65_RS135052869381..2869893-513WP_003413197.1Holliday junction resolvase RuvX-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T65078 WP_003413180.1 NZ_CP016794:c2866245-2865850 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T65078 NZ_CP016794:c2866245-2865850 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT65078 WP_003413183.1 NZ_CP016794:c2866487-2866242 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT65078 NZ_CP016794:c2866487-2866242 [Mycobacterium tuberculosis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB5WZ4
PDB5WZF

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U4BW31

References