Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2864277..2864986 Replicon chromosome
Accession NZ_CP016794
Organism Mycobacterium tuberculosis strain SCAID 320.0

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ26
Locus tag BEE65_RS13460 Protein ID WP_003413164.1
Coordinates 2864277..2864690 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag BEE65_RS13465 Protein ID WP_003413167.1
Coordinates 2864729..2864986 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEE65_RS13435 2859331..2860536 - 1206 WP_003413027.1 chorismate synthase -
BEE65_RS13440 2860644..2860958 + 315 WP_009937839.1 hypothetical protein -
BEE65_RS13445 2861254..2862465 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
BEE65_RS13450 2862592..2863251 + 660 WP_003902296.1 hypothetical protein -
BEE65_RS13455 2863248..2863910 + 663 WP_003905878.1 hypothetical protein -
BEE65_RS22185 2863907..2864184 + 278 Protein_2629 type II toxin-antitoxin system VapB family antitoxin -
BEE65_RS13460 2864277..2864690 + 414 WP_003413164.1 PIN domain nuclease Toxin
BEE65_RS13465 2864729..2864986 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
BEE65_RS13470 2864983..2865360 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
BEE65_RS13475 2865376..2865750 - 375 WP_003413177.1 hypothetical protein -
BEE65_RS13480 2865850..2866245 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
BEE65_RS13485 2866242..2866487 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
BEE65_RS13490 2866898..2867317 - 420 WP_003413190.1 A24 family peptidase -
BEE65_RS13495 2867329..2868138 - 810 WP_003413193.1 shikimate dehydrogenase -
BEE65_RS13500 2868135..2869388 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
BEE65_RS13505 2869381..2869893 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15045.00 Da        Isoelectric Point: 5.4673

>T65076 WP_003413164.1 NZ_CP016794:2864277-2864690 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAETFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Download         Length: 414 bp

>T65076 NZ_CP016794:2864277-2864690 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT65076 WP_003413167.1 NZ_CP016794:2864729-2864986 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT65076 NZ_CP016794:2864729-2864986 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ26

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References