Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2400344..2400873 Replicon chromosome
Accession NZ_CP016794
Organism Mycobacterium tuberculosis strain SCAID 320.0

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag BEE65_RS11270 Protein ID WP_003411124.1
Coordinates 2400344..2400661 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag BEE65_RS11275 Protein ID WP_003411127.1
Coordinates 2400658..2400873 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEE65_RS11240 2395365..2396441 + 1077 WP_003411110.1 hypothetical protein -
BEE65_RS11245 2396438..2396719 + 282 WP_003411112.1 hypothetical protein -
BEE65_RS11250 2396755..2397828 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
BEE65_RS11255 2397833..2398363 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
BEE65_RS11260 2398411..2399757 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
BEE65_RS11270 2400344..2400661 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BEE65_RS11275 2400658..2400873 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
BEE65_RS11280 2401128..2402186 + 1059 WP_003411129.1 hypothetical protein -
BEE65_RS11285 2402316..2402672 - 357 WP_003411130.1 hypothetical protein -
BEE65_RS11290 2402767..2403549 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
BEE65_RS11295 2403817..2404107 - 291 WP_003900476.1 YggT family protein -
BEE65_RS11300 2404269..2404925 - 657 WP_003411133.1 cell division protein SepF -
BEE65_RS11305 2404987..2405766 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T65073 WP_003411124.1 NZ_CP016794:c2400661-2400344 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T65073 NZ_CP016794:c2400661-2400344 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT65073 WP_003411127.1 NZ_CP016794:c2400873-2400658 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT65073 NZ_CP016794:c2400873-2400658 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References