Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1575754..1576409 Replicon chromosome
Accession NZ_CP016794
Organism Mycobacterium tuberculosis strain SCAID 320.0

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag BEE65_RS07420 Protein ID WP_003898861.1
Coordinates 1575754..1576155 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag BEE65_RS07425 Protein ID WP_003407272.1
Coordinates 1576152..1576409 (-) Length 86 a.a.

Genomic Context

BEE65_RS07410BEE65_RS07440BEE65_RS07445BEE65_RS07405BEE65_RS07415BEE65_RS07420BEE65_RS07425BEE65_RS07430BEE65_RS07435
Location: 1572689..1573723 (1035 bp)
Type: Others
Protein ID: WP_003407264.1
Location: 1578437..1579174 (738 bp)
Type: Others
Protein ID: WP_031647000.1
Location: 1579255..1581222 (1968 bp)
Type: Others
Protein ID: WP_003407285.1
Location: 1571226..1572611 (1386 bp)
Type: Others
Protein ID: WP_003407260.1
Location: 1573769..1575499 (1731 bp)
Type: Others
Protein ID: WP_009940170.1
Location: 1575754..1576155 (402 bp)
Type: Toxin
Protein ID: WP_003898861.1
Location: 1576152..1576409 (258 bp)
Type: Antitoxin
Protein ID: WP_003407272.1
Location: 1576492..1577451 (960 bp)
Type: Others
Protein ID: WP_003407276.1
Location: 1577476..1578438 (963 bp)
Type: Others
Protein ID: WP_003905554.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BEE65_RS074051571226..1572611-1386WP_003407260.1cytochrome P450-
BEE65_RS074101572689..1573723+1035WP_003407264.1AraC family transcriptional regulator-
BEE65_RS074151573769..1575499-1731WP_009940170.1PE family protein-
BEE65_RS074201575754..1576155-402WP_003898861.1type II toxin-antitoxin system VapC family toxinToxin
BEE65_RS074251576152..1576409-258WP_003407272.1ribbon-helix-helix domain-containing proteinAntitoxin
BEE65_RS074301576492..1577451-960WP_003407276.1alpha/beta hydrolase-
BEE65_RS074351577476..1578438-963WP_003905554.1alpha/beta hydrolase-
BEE65_RS074401578437..1579174+738WP_031647000.1lysoplasmalogenase-
BEE65_RS074451579255..1581222+1968WP_003407285.1primosomal protein N'-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T65058 WP_003898861.1 NZ_CP016794:c1576155-1575754 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T65058 NZ_CP016794:c1576155-1575754 [Mycobacterium tuberculosis]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT65058 WP_003407272.1 NZ_CP016794:c1576409-1576152 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT65058 NZ_CP016794:c1576409-1576152 [Mycobacterium tuberculosis]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A045ISB0

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TIK2

References