Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 692986..693632 Replicon chromosome
Accession NZ_CP016794
Organism Mycobacterium tuberculosis strain SCAID 320.0

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag BEE65_RS03080 Protein ID WP_003403122.1
Coordinates 692986..693378 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag BEE65_RS03085 Protein ID WP_003403125.1
Coordinates 693375..693632 (-) Length 86 a.a.

Genomic Context

BEE65_RS03065BEE65_RS03070BEE65_RS03075BEE65_RS03120BEE65_RS03080BEE65_RS03085BEE65_RS03090BEE65_RS03095BEE65_RS03100BEE65_RS03105BEE65_RS03110BEE65_RS03115
Location: 688648..690174 (1527 bp)
Type: Others
Protein ID: WP_003403112.1
Location: 690237..691379 (1143 bp)
Type: Others
Protein ID: WP_003911253.1
Location: 691384..692934 (1551 bp)
Type: Others
Protein ID: WP_003905349.1
Location: 698003..698314 (312 bp)
Type: Others
Protein ID: WP_003403164.1
Location: 692986..693378 (393 bp)
Type: Toxin
Protein ID: WP_003403122.1
Location: 693375..693632 (258 bp)
Type: Antitoxin
Protein ID: WP_003403125.1
Location: 693815..695050 (1236 bp)
Type: Others
Protein ID: WP_003403128.1
Location: 695301..695714 (414 bp)
Type: Others
Protein ID: WP_003403137.1
Location: 695711..695947 (237 bp)
Type: Others
Protein ID: WP_003403139.1
Location: 696051..696557 (507 bp)
Type: Others
Protein ID: WP_003900973.1
Location: 696671..697201 (531 bp)
Type: Others
Protein ID: WP_003917320.1
Location: 697185..697946 (762 bp)
Type: Others
Protein ID: WP_003403148.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BEE65_RS03065688648..690174+1527WP_003403112.1virulence factor Mce family protein-
BEE65_RS03070690237..691379+1143WP_003911253.1virulence factor Mce family protein-
BEE65_RS03075691384..692934+1551WP_003905349.1MCE family protein-
BEE65_RS03080692986..693378-393WP_003403122.1type II toxin-antitoxin system toxin ribonuclease C4Toxin
BEE65_RS03085693375..693632-258WP_003403125.1type II toxin-antitoxin system antitoxin VapB4Antitoxin
BEE65_RS03090693815..695050-1236WP_003403128.1ATP-binding protein-
BEE65_RS03095695301..695714-414WP_003403137.1type II toxin-antitoxin system VapC family toxin-
BEE65_RS03100695711..695947-237WP_003403139.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-
BEE65_RS03105696051..696557-507WP_003900973.1two component system sensor kinase HK1-
BEE65_RS03110696671..697201-531WP_003917320.1two component system sensor kinase HK2-
BEE65_RS03115697185..697946-762WP_003403148.1two-component system response regulator TcrA-
BEE65_RS03120698003..698314+312WP_003403164.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T65040 WP_003403122.1 NZ_CP016794:c693378-692986 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

>T65040 NZ_CP016794:c693378-692986 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT65040 WP_003403125.1 NZ_CP016794:c693632-693375 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp

>AT65040 NZ_CP016794:c693632-693375 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U4F8V4

Antitoxin

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Source
ID
Structure
AlphaFold DBG0TQ86

References