65025

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1818725..1819196 Replicon chromosome
Accession NZ_CP016757
Organism Cloacibacillus porcorum strain CL-84 (T)

Toxin (Protein)


Gene name pasB Uniprot ID A0A1B2I503
Locus tag BED41_RS08120 Protein ID WP_066744731.1
Coordinates 1818933..1819196 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A1B2I527
Locus tag BED41_RS08115 Protein ID WP_066744729.1
Coordinates 1818725..1818949 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED41_RS08095 1814009..1815358 - 1350 WP_066744723.1 DUF1446 domain-containing protein -
BED41_RS08100 1815375..1816148 - 774 WP_084002341.1 ABC transporter permease subunit -
BED41_RS08105 1816178..1817203 - 1026 WP_066744725.1 ABC transporter substrate-binding protein -
BED41_RS08110 1817221..1818003 - 783 WP_066744727.1 ABC transporter ATP-binding protein -
BED41_RS08115 1818725..1818949 + 225 WP_066744729.1 ribbon-helix-helix protein, CopG family Antitoxin
BED41_RS08120 1818933..1819196 + 264 WP_066744731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BED41_RS08130 1819460..1820380 - 921 WP_066744733.1 DMT family transporter -
BED41_RS08135 1820453..1822645 - 2193 WP_066744735.1 Eco57I restriction-modification methylase domain-containing protein -
BED41_RS08140 1822980..1823843 - 864 WP_066744737.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Relaxosome protein TraY

(4-34)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9961.68 Da        Isoelectric Point: 10.0064

>T65025 WP_066744731.1 NZ_CP016757:1818933-1819196 [Cloacibacillus porcorum]
MGWRIELSRQAEKELAAINKPDALRIAKYLAELEKLQDPRLRGKALSANLSGLWRYRIGDWRVLCRIEDGCLIVLVVQIG
HRSTVYG

Download         Length: 264 bp

>T65025 NZ_CP016757:1818933-1819196 [Cloacibacillus porcorum]
TTGGGCTGGAGGATTGAGCTTTCGCGGCAGGCAGAAAAAGAACTTGCCGCAATTAACAAACCCGACGCACTGCGCATCGC
CAAATACCTCGCTGAGCTCGAAAAACTACAAGATCCAAGACTCCGCGGTAAGGCGCTCTCGGCAAACCTTTCCGGCCTCT
GGCGCTACCGTATAGGTGACTGGCGTGTCTTATGTCGTATAGAGGATGGATGTCTCATCGTCCTCGTAGTGCAGATTGGA
CACCGAAGCACAGTCTACGGCTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8472.44 Da        Isoelectric Point: 4.4076

>AT65025 WP_066744729.1 NZ_CP016757:1818725-1818949 [Cloacibacillus porcorum]
MLAIRLDEKTESRLEDLSSKTGRTKTWYVRKAIETYIDDLEDAAIAASAYEEYLFDGGKSSPLEDVRRRLGLED

Download         Length: 225 bp

>AT65025 NZ_CP016757:1818725-1818949 [Cloacibacillus porcorum]
ATGCTTGCTATCCGTCTTGACGAAAAAACAGAAAGCCGTCTCGAAGATTTGTCCAGCAAAACAGGGCGAACAAAAACTTG
GTATGTTCGCAAAGCTATAGAGACTTATATTGACGACCTTGAGGATGCAGCTATCGCAGCCTCCGCCTACGAAGAATACC
TTTTTGACGGCGGAAAATCTTCACCGTTGGAAGACGTCAGGCGTCGCCTTGGGCTGGAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B2I503

Antitoxin

Source ID Structure
AlphaFold DB A0A1B2I527

References