Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1260957..1261518 Replicon chromosome
Accession NZ_CP016757
Organism Cloacibacillus porcorum strain CL-84 (T)

Toxin (Protein)


Gene name relE Uniprot ID A0A1B2I3S2
Locus tag BED41_RS05720 Protein ID WP_066743951.1
Coordinates 1260957..1261241 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B2I3V7
Locus tag BED41_RS05725 Protein ID WP_066743954.1
Coordinates 1261234..1261518 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BED41_RS05675 1256278..1256598 - 321 WP_066743933.1 hypothetical protein -
BED41_RS05680 1256769..1257557 - 789 WP_066743935.1 hypothetical protein -
BED41_RS05685 1257596..1257934 - 339 WP_066743937.1 hypothetical protein -
BED41_RS16410 1258033..1258488 - 456 WP_157102273.1 hypothetical protein -
BED41_RS05690 1258524..1258949 - 426 WP_066743939.1 helix-turn-helix domain-containing protein -
BED41_RS05700 1259400..1259582 + 183 WP_066743943.1 hypothetical protein -
BED41_RS05705 1259589..1259855 + 267 WP_066743945.1 helix-turn-helix transcriptional regulator -
BED41_RS05710 1260017..1260271 + 255 WP_157102274.1 hypothetical protein -
BED41_RS05715 1260255..1260734 + 480 WP_168160235.1 sigma-70 family RNA polymerase sigma factor -
BED41_RS05720 1260957..1261241 - 285 WP_066743951.1 type II toxin-antitoxin system YafQ family toxin Toxin
BED41_RS05725 1261234..1261518 - 285 WP_066743954.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BED41_RS05730 1261616..1262245 + 630 WP_066743959.1 terminase small subunit -
BED41_RS05735 1262238..1263047 + 810 WP_066743960.1 DEAD/DEAH box helicase family protein -
BED41_RS05740 1263014..1263598 + 585 WP_066743962.1 hypothetical protein -
BED41_RS05745 1263660..1263872 + 213 WP_066743964.1 hypothetical protein -
BED41_RS05750 1264210..1264431 - 222 WP_066743966.1 hypothetical protein -
BED41_RS05755 1264680..1266218 + 1539 WP_066743968.1 glutamine-hydrolyzing GMP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(W) - 1238543..1288955 50412


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-90)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10740.44 Da        Isoelectric Point: 9.9516

>T65024 WP_066743951.1 NZ_CP016757:c1261241-1260957 [Cloacibacillus porcorum]
MSKYTVKYTSRFKKEAKRAEKQGKNMALLKTTAALLSSGEPLPPKFKDHALTGNWEGYRECHLSPDWLLIYLIENDVLVL
TLTRTGSHAEIFNK

Download         Length: 285 bp

>T65024 NZ_CP016757:c1261241-1260957 [Cloacibacillus porcorum]
ATGAGTAAATACACGGTCAAGTACACGTCCAGATTTAAAAAAGAGGCGAAGCGCGCCGAAAAACAGGGCAAGAACATGGC
GTTGCTGAAAACAACGGCTGCGCTTCTCTCCTCCGGCGAGCCCTTGCCGCCTAAATTCAAAGATCATGCCCTCACCGGCA
ACTGGGAAGGTTATCGAGAGTGCCATCTCTCGCCGGACTGGCTGCTCATCTATCTCATCGAAAACGACGTCCTTGTCCTC
ACCCTCACCCGTACCGGCAGCCACGCCGAGATATTCAACAAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10523.06 Da        Isoelectric Point: 4.6627

>AT65024 WP_066743954.1 NZ_CP016757:c1261518-1261234 [Cloacibacillus porcorum]
MATKTAMLHIRIEPEIKEEADYIFGQIGITTSDAVKIFLHKAIYSSGFPFEVTAPTYNAETIAAMKEAKRIAHDPNVKGY
TDMDELMKDLLADE

Download         Length: 285 bp

>AT65024 NZ_CP016757:c1261518-1261234 [Cloacibacillus porcorum]
ATGGCCACCAAGACCGCCATGCTGCACATAAGGATAGAACCGGAGATAAAAGAAGAAGCCGATTACATCTTCGGGCAAAT
AGGCATCACGACCTCCGACGCCGTTAAAATATTCCTGCACAAAGCCATCTATTCATCCGGCTTTCCGTTTGAAGTGACCG
CACCGACATACAACGCCGAGACCATCGCGGCCATGAAAGAGGCTAAACGCATCGCGCACGATCCGAACGTAAAAGGCTAC
ACCGACATGGACGAGCTGATGAAAGACCTGTTGGCGGATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B2I3S2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B2I3V7

References