Detailed information of TA system TA065022

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-MazE
• Location: 3500438..3501051
• Replicon: chromosome
• Accession: NZ_CP016756
• Organism: Stenotrophomonas nitritireducens strain 2001

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: BCV67_RS14895
• Protein ID: WP_062168809.1
• Coordinates: 3500689..3501051 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: A0A126NKU1
• Locus tag: BCV67_RS14890
• Protein ID: WP_062168811.1
• Coordinates: 3500438..3500695 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCV67_RS14865	3495523..3496287	+	765	WP_062168819.1	MBL fold metallo-hydrolase	-
BCV67_RS14875	3496971..3497288	+	318	WP_062168817.1	quaternary ammonium compound efflux SMR transporter SugE	-
BCV67_RS14880	3497297..3497749	-	453	WP_062168816.1	GNAT family N-acetyltransferase	-
BCV67_RS14885	3497871..3500222	-	2352	WP_062168814.1	GH92 family glycosyl hydrolase	-
BCV67_RS14890	3500438..3500695	+	258	WP_062168811.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BCV67_RS14895	3500689..3501051	+	363	WP_062168809.1	type II toxin-antitoxin system ChpB family toxin	Toxin
BCV67_RS20180	3501269..3501439	+	171	WP_156455857.1	hypothetical protein	-
BCV67_RS20185	3501436..3501573	+	138	WP_156455856.1	hypothetical protein	-
BCV67_RS14900	3502051..3503007	-	957	WP_062168807.1	hypothetical protein	-
BCV67_RS14905	3503357..3504133	+	777	WP_156455855.1	hypothetical protein	-
BCV67_RS14910	3504175..3504477	-	303	WP_062168803.1	DUF3892 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3472404..3504477	32073

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-116)

Antitoxin

• Antitoxin PemI-like (1-85)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 12483.29 Da
• Isoelectric Point: 8.9971

>T65022 WP_062168809.1 NZ_CP016756:3500689-3501051 [Stenotrophomonas nitritireducens]
VVSRPRFDRGDIIRVQLNPSAGQEMQGDMRPALVLSPAPFNGTGLAIVAPITQGGMVGRNAGFAVSLSATGTETQGVVLV
NHLRSMDLSARGARKVERAPASVVDEALAKVATFLGESVE

Nucleotide

• Length: 363 bp

>T65022 NZ_CP016756:3500689-3501051 [Stenotrophomonas nitritireducens]
GTGGTGAGTCGCCCGCGATTTGATCGCGGCGACATCATCCGGGTTCAGCTCAACCCCAGCGCAGGCCAGGAAATGCAGGG
CGACATGCGTCCGGCGCTTGTCCTGAGTCCGGCGCCATTCAACGGCACGGGCTTGGCGATCGTTGCCCCGATCACACAGG
GCGGAATGGTGGGGCGAAATGCGGGGTTCGCGGTTTCGCTGTCAGCGACGGGCACCGAGACGCAGGGCGTGGTCCTGGTC
AACCACCTGCGAAGCATGGATTTGAGCGCGCGCGGTGCACGAAAGGTGGAGCGAGCGCCTGCCAGTGTTGTGGATGAGGC
GTTGGCGAAGGTGGCTACGTTTCTTGGGGAATCGGTGGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9245.51 Da
• Isoelectric Point: 4.6855

>AT65022 WP_062168811.1 NZ_CP016756:3500438-3500695 [Stenotrophomonas nitritireducens]
MHAKIQRWGNSAAVRLPASILKAMDLGSGDTLEIGVEDGTLILTPVKVRPRYQLSELLAQCDLSAPQDEELSAWNSSKPV
GNEAW

Nucleotide

• Length: 258 bp

>AT65022 NZ_CP016756:3500438-3500695 [Stenotrophomonas nitritireducens]
ATGCACGCCAAAATTCAGCGTTGGGGCAATAGCGCAGCCGTGCGCCTGCCTGCGTCCATTCTCAAAGCCATGGATCTGGG
CAGTGGTGACACGCTCGAGATTGGCGTCGAAGACGGCACGTTGATCCTGACGCCGGTCAAGGTGCGGCCCCGCTATCAGT
TGTCGGAGTTGCTGGCGCAGTGTGATTTGAGCGCCCCGCAGGACGAAGAGCTGTCTGCCTGGAACAGCAGCAAGCCGGTA
GGGAACGAAGCGTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A126NKU1