Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3525113..3525591 Replicon chromosome
Accession NZ_CP016755
Organism Escherichia coli strain FORC_044

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag FORC44_RS19650 Protein ID WP_001303876.1
Coordinates 3525304..3525591 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag FORC44_RS19645 Protein ID WP_000536233.1
Coordinates 3525113..3525304 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC44_RS19610 3520518..3521288 - 771 WP_000450992.1 DUF1627 domain-containing protein -
FORC44_RS19615 3521310..3522056 - 747 WP_000788751.1 ATP-binding protein -
FORC44_RS19620 3522063..3523153 - 1091 Protein_3571 DNA-binding protein -
FORC44_RS19625 3523232..3523687 + 456 WP_000273724.1 hypothetical protein -
FORC44_RS19630 3523894..3524319 - 426 WP_000693855.1 Rha family transcriptional regulator -
FORC44_RS19635 3524303..3524575 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
FORC44_RS19640 3524684..3525085 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
FORC44_RS19645 3525113..3525304 + 192 WP_000536233.1 hypothetical protein Antitoxin
FORC44_RS19650 3525304..3525591 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FORC44_RS19665 3525869..3526024 + 156 WP_000379575.1 DUF1391 family protein -
FORC44_RS19675 3526166..3526555 + 390 WP_000394511.1 hypothetical protein -
FORC44_RS19680 3526742..3526927 - 186 WP_001133046.1 hypothetical protein -
FORC44_RS19690 3527501..3527689 + 189 WP_000413705.1 cell division inhibition protein DicB -
FORC44_RS19695 3527686..3527877 + 192 WP_001098307.1 DUF1482 family protein -
FORC44_RS19700 3527971..3530442 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T65011 WP_001303876.1 NZ_CP016755:3525304-3525591 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T65011 NZ_CP016755:3525304-3525591 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT65011 WP_000536233.1 NZ_CP016755:3525113-3525304 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT65011 NZ_CP016755:3525113-3525304 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References