Detailed information of TA system TA064986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1368614..1369156
• Replicon: chromosome
• Accession: NZ_CP016753
• Organism: Leptotrichia sp. oral taxon 498 strain F0590

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BCB68_RS06810
• Protein ID: WP_094080089.1
• Coordinates: 1368881..1369156 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BCB68_RS06805
• Protein ID: WP_094080088.1
• Coordinates: 1368614..1368877 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCB68_RS06770	1363715..1364254	+	540	WP_094080081.1	hypothetical protein	-
BCB68_RS06775	1364289..1365089	+	801	WP_094080082.1	DUF2262 domain-containing protein	-
BCB68_RS06780	1365289..1365663	+	375	WP_094080083.1	hypothetical protein	-
BCB68_RS06785	1366092..1366562	+	471	WP_094080084.1	hypothetical protein	-
BCB68_RS06790	1366581..1367636	+	1056	WP_094080085.1	prolyl oligopeptidase family serine peptidase	-
BCB68_RS06795	1367751..1368014	+	264	WP_094080086.1	endonuclease	-
BCB68_RS06800	1368050..1368508	+	459	WP_094080087.1	hypothetical protein	-
BCB68_RS06805	1368614..1368877	+	264	WP_094080088.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BCB68_RS06810	1368881..1369156	+	276	WP_094080089.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BCB68_RS06815	1369171..1369956	+	786	WP_094080090.1	hypothetical protein	-
BCB68_RS06820	1369986..1370072	+	87	Protein_1312	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
BCB68_RS06825	1370087..1370533	+	447	WP_094080091.1	OmpA family protein	-
BCB68_RS06830	1370580..1371638	+	1059	WP_094080092.1	3-isopropylmalate dehydrogenase	-
BCB68_RS06835	1371924..1373627	+	1704	WP_094080093.1	ABC-ATPase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-75)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10867.83 Da
• Isoelectric Point: 10.1238

>T64986 WP_094080089.1 NZ_CP016753:1368881-1369156 [Leptotrichia sp. oral taxon 498]
MKLTIKTTKRFDKDLKKLKKRKYDLILLAQVINKLSDSEILPEKYRDHYLAGDYKGFRECHIQPDWLLIYKIEKNILVLT
LSRTGTHSDLF

Nucleotide

• Length: 276 bp

>T64986 NZ_CP016753:1368881-1369156 [Leptotrichia sp. oral taxon 498]
ATGAAATTGACAATAAAGACGACCAAAAGGTTTGATAAGGACTTGAAAAAATTAAAGAAAAGAAAATATGATTTAATATT
ACTGGCACAGGTTATTAATAAATTATCTGATAGTGAAATTTTGCCTGAAAAATATAGAGATCATTATCTTGCTGGCGATT
ATAAAGGATTTAGAGAATGTCATATTCAACCTGATTGGCTCTTAATTTATAAAATTGAAAAAAATATTTTGGTTTTGACA
TTGTCGAGAACTGGGACACATTCGGATTTGTTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9812.42 Da
• Isoelectric Point: 4.8779

>AT64986 WP_094080088.1 NZ_CP016753:1368614-1368877 [Leptotrichia sp. oral taxon 498]
MATVTARVDENVKKEAETLFKKMGLNMSTAMNLFLKKCILEQGIPFELKVPNKETLKAMQETDDILSGKIERKGYNSAEE
LFEDLGV

Nucleotide

• Length: 264 bp

>AT64986 NZ_CP016753:1368614-1368877 [Leptotrichia sp. oral taxon 498]
ATGGCTACAGTAACAGCTAGAGTTGATGAAAATGTGAAAAAGGAAGCAGAAACTTTGTTTAAGAAAATGGGGCTTAATAT
GAGTACTGCTATGAATTTATTTTTGAAGAAGTGTATTTTGGAGCAGGGGATTCCGTTTGAATTGAAAGTGCCGAATAAGG
AAACTTTAAAGGCAATGCAGGAAACTGATGATATTTTGAGTGGTAAAATTGAAAGAAAAGGGTATAATAGTGCTGAAGAA
TTATTTGAGGATTTAGGGGTTTAG