Detailed information of TA system TA064985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 197421..197970
• Replicon: chromosome
• Accession: NZ_CP016753
• Organism: Leptotrichia sp. oral taxon 498 strain F0590

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BCB68_RS00850
• Protein ID: WP_094079112.1
• Coordinates: 197686..197970 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BCB68_RS00845
• Protein ID: WP_094079111.1
• Coordinates: 197421..197699 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCB68_RS00820	193277..193843	-	567	WP_094079109.1	nucleotide exchange factor GrpE	-
BCB68_RS00825	193862..194866	-	1005	WP_094079110.1	heat-inducible transcriptional repressor HrcA	-
BCB68_RS00830	195181..195773	+	593	Protein_164	DUF3800 domain-containing protein	-
BCB68_RS00835	196621..196806	+	186	WP_021743949.1	hypothetical protein	-
BCB68_RS00840	196784..197359	+	576	WP_021743948.1	hypothetical protein	-
BCB68_RS00845	197421..197699	+	279	WP_094079111.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BCB68_RS00850	197686..197970	+	285	WP_094079112.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BCB68_RS00855	198257..198583	-	327	WP_094079113.1	helix-turn-helix domain-containing protein	-
BCB68_RS00860	198791..199390	+	600	WP_094079114.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
BCB68_RS00865	199387..200220	+	834	WP_094079115.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
BCB68_RS00870	200385..200588	+	204	WP_094079116.1	XRE family transcriptional regulator	-
BCB68_RS00875	200685..201044	+	360	WP_094079117.1	hypothetical protein	-
BCB68_RS00880	201079..201612	+	534	WP_094079118.1	hypothetical protein	-
BCB68_RS00885	201652..202536	+	885	WP_094079119.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-86)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11227.46 Da
• Isoelectric Point: 10.4168

>T64985 WP_094079112.1 NZ_CP016753:197686-197970 [Leptotrichia sp. oral taxon 498]
MKMNKYNLKYTNRFSKDLKLIKKRGYNLKLLEKVVEILINREKLSVKNKDYALKNKYLGYRECCITSDWLLVYKIKGEEL
ILLTTKTKTPSSLF

Nucleotide

• Length: 285 bp

>T64985 NZ_CP016753:197686-197970 [Leptotrichia sp. oral taxon 498]
ATGAAGATGAATAAGTATAATTTAAAATATACAAATAGGTTTTCTAAAGATTTAAAATTAATAAAAAAACGTGGGTATAA
TCTAAAATTACTTGAAAAAGTAGTTGAAATATTGATTAATCGTGAAAAATTGTCTGTAAAAAATAAAGATTATGCTTTAA
AAAATAAATATTTAGGGTATCGTGAGTGCTGTATAACATCTGATTGGTTGTTAGTATATAAAATAAAAGGTGAGGAATTA
ATATTACTAACAACGAAAACAAAAACTCCGAGCAGTTTATTTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10632.19 Da
• Isoelectric Point: 5.2273

>AT64985 WP_094079111.1 NZ_CP016753:197421-197699 [Leptotrichia sp. oral taxon 498]
MPTVSTSIKIDAKTKKEAQELFKDMGMSLTAAINIFLKQAVREQRIPFYVGEPKYKEEVYQAMKDVEQGKNLSKSYHSAR
EMIEDILKDEDE

Nucleotide

• Length: 279 bp

>AT64985 NZ_CP016753:197421-197699 [Leptotrichia sp. oral taxon 498]
ATGCCAACGGTTAGTACAAGTATAAAAATAGATGCCAAAACAAAGAAAGAAGCACAAGAATTATTTAAAGATATGGGAAT
GAGTTTAACTGCAGCAATAAATATATTCTTGAAACAGGCAGTAAGAGAGCAGAGAATACCTTTTTATGTTGGAGAGCCAA
AATATAAGGAAGAAGTTTATCAAGCTATGAAAGATGTAGAACAAGGTAAGAATTTGAGCAAGTCTTATCATAGTGCTAGA
GAAATGATAGAGGATATTTTGAAAGATGAAGATGAATAA